乳酸萃取发酵耦合的数学模拟方法  

MODELING METHOD OF FERMENTATION WITH CONTINUOUS LACTIC ACID REMOVAL BY EXTRACTION UTILIZING CHEMICAL COMPLEXATION

作　　者：戴猷元[1] 胡徐腾[1] 

机构地区：[1]清华大学化学工程系

出　　处：《计算机与应用化学》1998年第4期217-223,共7页Computers and Applied Chemistry

摘　　要：萃取发酵耦合过程是用于减少产物抑制的技术，它可以通过原位方式或外部循环不断移走发酵产物。本文以乳酸萃取发酵耦合过程为对象，提出了过程模拟的数学模型。模型中既考虑了发酵菌株生长动力学，也考虑了乳酸在水相和有机相中的萃取平衡。不同的操作条件下模拟结果表明，ｐＨ的选择要兼顾发酵菌株的生长动力学、萃取溶剂中产物浓度和负载溶剂的再生等三个方面。乳酸萃取发酵耦合过程的实施关键在于把寻求萃取剂的较强的萃取能力和再生的经济性以及合适的生物相容性结合起来。Extractive fermentation is a technique that can be used to reduce end-product inhibition by removing fermentation products in situ or in an external recycle loop. A model is presented for fermentation with continuous lactic acid removal by extraction utilizing chemical complexation. The model is formulated considering the kinetics of cell growth and the equilibrium distribution of lactic acid between aqueous and organic phases. Simulations have been carried out for different sets of operating conditions. The choice of pH balances faster kinetics at higher pH against lower product concentrations in the solvent and more difficult regeneration. A key need is for liquid extractants combining stronger uptake ability with economical regeneration and satisfactory biocompatibility.

关 键 词：萃取发酵 乳酸 数学模拟 耦合 发酵 

分 类 号：TQ921.3[轻工技术与工程—发酵工程]