桐油甘油三酯对体外培养的人体肿瘤细胞的毒性  

Cytotoxic effect of triacylglycerols in tung oil on human tumor cells cultured in vitro

作　　者：傅伟昌[1,2] 顾小红[2] 俞惠新[3] 汤坚[2] 蒋再良 

机构地区：[1]吉首大学食品科学研究所,湖南吉首416000 [2]江南大学食品科学与技术国家重点实验室,江苏无锡214122 [3]江苏省原子医学研究所,江苏无锡214063 [4]无锡市富仁生物科技有限公司,江苏宜兴214252

出　　处：《中国油脂》2009年第12期48-53,共6页China Oils and Fats

摘　　要：以纯度为96%的α-桐酸作为对照,考察了从桐油中经NARP-HPLC分离得到的3组含共轭亚麻酸的甘油三酯对人体肿瘤细胞株ECA-109(食管癌)、SGC-7901(胃癌)、Bel-7402(肝癌)、LS-174-T(结肠癌)、KB(口腔癌)和正常细胞株L02(肝细胞)的细胞毒性。结果发现α-桐酸对KB、Bel-7402和SGC-7901细胞的毒性明显弱于3组含共轭亚麻酸的甘油三酯。结果提示,除了α-桐酸的共轭三烯结构是桐油甘油三酯的细胞毒性的物质基础之外,含共轭亚麻酸的甘油三酯的分子结构对其抗肿瘤功效也有重要贡献。The cytotoxic which were isolated from （ esophageal carcinoma） （ colon carcinoma） , KB effects of three groups of triacylglycerols containing conjugated linolenic acid tung oil by NARP - HPLC on five human tumor cell lines including ECA - 109 , SGC-7901 （carcinoma ventrieuli）, Bel-7402 （hepatoma）, LS- 174-T （mouth epidermal carcinoma）, and human normal cell line L02 （liver cell） were investigated, and α - eleostearic acid with a purity of 96% was used as control. The results showed that α - eleostearic acid showed weaker cytotoxicity than three groups of triaeylglycerols for KB, Bel - 7402, SGC - 7901 cell lines. The eytotoxic effect of α - eleostearie acid and triacylglycerols of tung oil against human tumor cells may be attributable to conjugated trienoic structure. The study suggested that molecular structures of triaeylglycerols containing conjugated linolenic acids were important for their eytotoxicity to human tumor cells.

关 键 词：桐油 甘油三酯 α-桐酸 细胞毒性作用 

分 类 号：R73-3[医药卫生—肿瘤]