脂源性分泌因子leptin、resistin、adiponectin、visfatin mRNA在子痫前期患者胎盘组织中表达及意义  

Leptin,resistin,adiponectin,and visfatin mRNA levels in placental tissues of patients with preeclampsia

作　　者：王欣[1] 王小青[1] 刘晓梅[1] 花向东[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院产科,江苏南京210004

出　　处：《南京医科大学学报（自然科学版）》2009年第12期1724-1726,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨子痫前期患者胎盘组织中脂源性分泌因子瘦素(leptin)、抵抗素(resistin)、脂联素(adiponectin)、内脂素(visfatin)mRNA表达水平及其意义。方法:采用RT-PCR方法测定36例正常足月妊娠妇女(A组)、24例轻度子痫前期患者(B组)和17例重度子痫前期患者(C组)胎盘组织中脂源性分泌因子leptin、resistin、adiponectin、visfatin mRNA表达水平。结果:①C组leptin、resistin mRNA表达水平分别为1.361±0.261、1.515±0.177,显著高于B组的0.898±0.201、1.055±0.113和A组的0.559±0.175、0.508±0.119(P<0.05);②C组adiponectin mRNA表达水平为0.222±0.115,显著低于B组的0.776±0.176和A组的1.422±0.193(P<0.05);③C组visfatin基因mRNA表达水平为0.253±0.119,显著低于B组的1.298±0.193和A组的1.308±0.208(P<0.05),B组与A组比较无显著差异(P>0.05)。结论:脂源性分泌因子leptin、resistin、adiponectin、visfatin在子痫前期的发病中有重要作用,可能参与了胰岛素抵抗的病理生理过程。Objective：To investigate the levels of leptin,resistin,adiponectin and visfatin mRNA expression in placental tissues of patients with preeclampsia.Methods：The levels of leptin,resistin,adiponectin and visfatin mRNA expression in placental tissues of 36 healthy term pregnant women（Group A）,24 patient with mild preeclampsia（Group B）,and 17 patients with severe preeclampsia（Group C）were examined by RT-PCR.Results：①Expression of leptin and resistin mRNA in placental tissues in Group C（1.361± 0.261、1.515±0.177）was significantly higher than that in Group A（0.559±0.175、0.508±0.119）and Group B（0.898±0.201、1.055± 0.113）（P 〈 0.05）,and was higher in Group B than that in Group A（P 〈 0.05）;②Expression of adiponectin mRNA was significantly lower in Group C（0.222±0.115）compared with Group A（1.422±0.193）and Group B（0.776±0.176）（P 〈 0.05）,and was lower in the Group B than that in the Group A（P 〈 0.05）;③Expression of visfatin mRNA was significantly lower in Group C（0.253±0.119）（P 〈 0.05）compared with Group A（1.308±0.208）and Group B（1.298±0.193）,while no statistical differences were observed between Group A and B（P 〉 0.05）.Conclusion：leptin,resistin,adiponectin and visfatin play an important role in the pathogenesis and de velopment of preeclampsia,and may induce insulin resistance.

关 键 词：LEPTIN RESISTIN ADIPONECTIN VISFATIN 子痫前期 胎盘 

分 类 号：R714.244[医药卫生—妇产科学]