肝特异性生物活性肽研究进展  

Advances in research on liver-specific biologically active peptides

作　　者：常菁[1] 崔春萍[1] 吴祖泽[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《军事医学科学院院刊》2009年第6期577-579,共3页Bulletin of the Academy of Military Medical Sciences

基　　金："863"课题(2006AA02Z182)资助项目;国家自然科学基金(30800558)资助项目

摘　　要：肝脏是人体内最重要的器官之一,具有强大的再生能力。肝再生的调控机制非常复杂,众多因子参与其中,但大多数因子,类似肝细胞生长因子(HGF)、表皮生长因子(EGF)都不具备肝细胞作用的特异性。近年来,本实验室从新生小牛的肝脏中分离得到了能够特异性地促进肝细胞增殖、促进70%肝切除小鼠肝再生的物质并将其命名为HPPCn。因此,结合本实验室的工作对肝刺激物(HSS)、肝再生增强因子(ALR)、HPS、HPPCn等具有肝特异性作用的生物活性肽的研究进展以及相互之间的异同加以综述。The liver is an important organ of the body,with an extraordinary capacity for responding to physical or chemical injuries by regenerating.The mechanisms behind liver regeneration are very complicated as hundreds of substances are involved.However,most of them are not liver-specific,such as HGF,EGF etc.We recently isolated a pure protein with hepatic stimulatory activity from the extract of a weanling calf liver and named its hepatopoietin Cn （HPPCn）.This paper,with reference to our own work,mainly reviews the development and bioactivity about hepatic stimulator substance （ HSS ）, augmenter of liver regeneration （ ALR）, hepassocin （HPS） and HPPCn, which are liver-specific biologically active peptides.

关 键 词：肝再生 肝细胞 细胞增殖 肝细胞生长因子 表皮生长因子 肝刺激物 肝再生增强因子 HPS HPPCn 生物活性肽 

分 类 号：R575[医药卫生—消化系统]