胼胝体发育不良临床、磁共振成像分析(附116例)  

Agenesis or dysgenisis of corpus callosum:Clinical and MRI findings in a series of 116 patients

作　　者：杜鹃[1] 沈璐[1] 廖伟华[1] 王峻岭[1] 唐北沙[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410008

出　　处：《卒中与神经疾病》2010年第1期28-31,共4页Stroke and Nervous Diseases

基　　金：国家"十五"科技攻关计划课题资助项目(2004BA720A03);国家"十一五"支撑重大项目(2006BA105A07);国家自然科学基金资助项目(30671151);湖南省杰出青年基金资助项目(2007JJ1005)

摘　　要：目的探讨胼胝体发育不良(AgCC)的临床和MRI表现。方法将患者分为3组:(1)原发性单纯性AgCC组;(2)原发性AgCC合并其他脑发育畸形组;(3)继发性AgCC组,分析其临床及MRI表现。结果胼胝体变薄是最常见的畸形,原发性AgCC合并其他脑发育畸形组更易有胼胝体完全缺如、脑室扩大、生长发育迟缓、智力低下。结论原发性AgCC合并其他脑发育畸形组的临床表现较原发性单纯性AgCC组重。Objective To assess their clinical and brain MRI manifestation.Methods The 116 patients with agenesis or dysgenisis of corpus callosum（AgCC） were classified in one of the following four groups based on the additional malformations in the central nervous system,or AgCC associated with other clinical events：（1） primary AgCC without substantial involvement of other systems;（2） primary AgCC associated with other malformations in the central nervous systems;（3） acquired AgCC caused by other clinical events.Results We find thin corpus callosum is the most common type of AgCC;primary AgCC associated with other malformations in the central nervous systems are commonly associated with ventricle dilation and presented with development delay and intelligence disability.Conclusions We suppose patients with other central nervous system malformations showed severer clinical manifestation than primary isolate AgCC.

关 键 词：胼胝体发育不良 临床表现 头部MRI 

分 类 号：R741[医药卫生—神经病学与精神病学]