中国人群5-羟色胺2A受体基因中T102C多态性与精神分裂症的联系  

Analysis of Association Between T102C Polymorphism in the Serotonin 2A Receptor Gene and Schizophrenia in Chinese Population

作　　者：李胜[1,2,3] 顾牛范[1,2,3] 冯国鄞[1,2,3] 刘万清[1,2,3] 沈韬 贺林[1,2,3] 

机构地区：[1]中国科学院上海生命科学研究中心 [2]上海市精神卫生中心 [3]中国科学院上海脑研究所

出　　处：《遗传》1998年第6期14-16,共3页Hereditas（Beijing)

基　　金：中国科学院及上海市科委的经费支助

摘　　要：在研究５－羟色胺２Ａ受体基因多态性与精神分裂症的关联分析中，调查了２０２例精神分裂症患者及２０２例正常对照。各相匹配组间比较未发现基因型和等位基因频率的显著性差异。结果提示，在中国人群中５－羟色胺２Ａ受体的静态Ｔ１０２Ｃ突变与精神分裂症之间不存在关联。Association study between in the T102C polymorphism serotonin 2A receptor gene and schizophrenia was performed in 202 schizophrenics and 202 normal controls No significant differences of genotype and allele frequencies between the matched groups were found Our results, which are different from some other studies, excluded the association between a silent T102C change and schizophrenia in the Chinese population

关 键 词：精神分裂症 T102C多态性 中国人群 

分 类 号：R749.3[医药卫生—神经病学与精神病学] Q987[医药卫生—临床医学]