急性非淋巴细胞白血病的细胞和分子遗传学研究进展  

Research Progress on Cellular and Molecular Genetics of Acute Non-lymphocytic Leukemia——Review

作　　者：熊文艳[1] 涂三芳[1] 陆志刚[1] 李玉华[1] 

机构地区：[1]南方医科大学珠江医院血液科输血科,广东广州510282

出　　处：《中国实验血液学杂志》2010年第2期536-539,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金(编号30500607);广东省自然科学基金重点项目(编号9251051501000007)资助

摘　　要：随着细胞与分子遗传学技术在急性白血病(AL)的研究进展中的运用,AL的诊断分型已由1976年提出的以形态学为主的FAB分型发展到2001年的MICM分型,突出体现了细胞和分子遗传学的改变在AL诊断分型的重要地位。除此之外,细胞和分子遗传学改变还对急性白血病的危险度分层、预后判断、治疗指导及新药研发起着重要的指导作用。本文将论述染色体异常和融合基因的表达对急性非淋巴细胞性白血病(ANLL)的诊断分型、预后评估和治疗的指导作用,并对染色体核型正常的ANLL几种常见的基因突变对疾病预后评估做个总结。近年来,对ANLL各型白血病分子细胞遗传学机制的进一步阐释有助于开发新的白血病治疗策略。With the extensive application of cellular and molecular genetic techniques in the research of acute leukemia （AL）, the diagnosis of AL type has been developed from FAB typing which was based on morphological classification in 1976 to MICM typing in 2001. This progress highlights the importance of cellular and molecular genetic changes in the diagnosis of leukemia. The cellular and molecular genetic abnormalities in acute leukemia can make the stratification of risk and give the guidance for prognosis and treatment, which is also critical for the development of new drugs. This article has focused on chromosomal abnormalities, fusion gene expression and their relationship with the teukemia diagnosis, prognosis and treatment. This article is also a concise review on several common gene mutations in cytogenetics of ANLL for the assessment of disease prognosis. In recent years, further exploration of molecular cytogenetic mechanisms of various types of leukemia in ANLL contributed to the development of new therapeutic strategy for leukemia.

关 键 词：急性非淋巴细胞白血病 分子遗传学 染色体异常 融合基因 

分 类 号：R733.71[医药卫生—肿瘤]