沙枣多糖抗疲劳作用及其机制的研究  

Anti-fatigue Effect and Mechanism of Polysaccharides from Eleagnus angustifolius L.

作　　者：丁玉松[1] 王忠[2] 马儒林[1] 冯刚玲[1] 徐上知[1] 吕凤莲[1] 唐美娥[1] 郑荣华[1] 

机构地区：[1]新疆石河子大学医学院预防医学系,新疆石河子832003 [2]新疆医科大学医学实验动物中心,新疆乌鲁木齐830054

出　　处：《食品科学》2010年第11期255-257,共3页Food Science

基　　金：石河子大学高层次人才科研启动资金专项项目(RCZX200790)

摘　　要：目的:探讨沙枣多糖(EAP)的抗疲劳生物功效及其机制。方法:取健康雄性清洁级ICR小鼠192只,随机分为4批,每批48只,分别进行负重游泳、肝糖原测定、血清尿素氮和血乳酸测定实验。每批动物再随机分为4组,即正常对照组、EAP低剂量组(100mg/(kgbw·d))、EAP中剂量组(500mg/(kgbw·d))、EAP高剂量组(1000mg/(kgbw·d)),连续灌胃30d后分别测定负重游泳时间、肝糖原含量、血清尿素氮和血乳酸含量。结果:EAP中、高剂量组能延长小鼠负重游泳时间;EAP各剂量组均能增加肝糖原含量;EAP低、高剂量组能够减少血清尿素氮含量;EAP中、高剂量组能降低血乳酸含量。结论:EAP具有明显的抗疲劳作用。Objective：To explore the anti-fatigue effect and mechanism of polysaccharides from Eleagnus angustifolius L.Methods：A total of 192 Kunming mice were randomly divided into 4 batches,each of which consisted of 4 groups：EAP groups at the dosages of low（100 mg/（kg bw·d））,middle（500 mg/（kg bw·d）） and high（1000 mg/（kg bw·d）） levels,and the control group.Each mouse was administered once a day for 30 days.After the end of the administration,all the mice were evaluated for their weight-loaded swimming duration and the contents of hepatic glycogen,blood urea nitrogen and blood lactic acid.Results：EAP at the high and middle dosages could prolong weight-loaded swimming duration,and decrease blood lactic acid level of mice.Hepatic glycogen content exhibited an increase in all groups administered EAP.In addition,a decline of blood urea nitrogen was observed in mice administered EAP at the high and low dosages.Conclusion：EAP could alleviate physical fatigue of mice.

关 键 词：沙枣多糖 抗疲劳 机制 保健食品 

分 类 号：R151.2[医药卫生—营养与食品卫生学]