叶黄素和玉米黄质治疗年龄相关性黄斑变性的多焦视网膜电图变化观察  

Changes of multifocal electroretinography after treatment of lutein and zeaxanthin for age-related macular degeneration

作　　者：李慧丽 陈熙 犹爱林 万迪玲 匡毅 王爽传 

机构地区：[1]重庆市第八人民医院眼科,重庆400015

出　　处：《中国实用眼科杂志》2010年第7期782-784,共3页Chinese Journal of Practical Ophthalmology

基　　金：重庆市医学科技计划项目（2008-2-332）

摘　　要：目的 应用多焦视网膜电图（multifocal electroretinography,mfERC）评价叶黄素（lutein）和玉米黄质（zeaxanthin）治疗年龄相关性黄斑变性（age-related macular degeneration,ARMD）的视网膜功能变化情况.方法 ARMD患者6例9只眼在接受叶黄素和玉米黄质治疗前及治疗后100d分别对各患眼5个环状视网膜区域进行b波反应密度的测量比较.记录以黄斑中心凹为中心呈同心圆排列的5个环区,自内至外分别是1环（2.18度）,2环（7.46度）,3环（12.36度）,4环（19.66度）和5环（29.75度）的b波反应振幅密度,应用EPi Info统计软件中两个独立样本的t检验进行统计学分析.结果 9只眼ARMD患者治疗前后mf-ERG b波反应振幅密度比较,1,2,3,4,5环各环的振幅密度均明显提高,与治疗前相比差异具有统计学意义（P〈0.05）.结论 mf-ERG 显示叶黄素和玉米黄质治疗能有效提高ARMD患者mf-ERG的b波反应振幅密度,改善患眼视网膜光感受器功能.Objective To observe the changes of retina function and to evaluate the efficacy of lutein and zeaxanthin for age-related macular degeneration by multifocal electroretinography.Methods Six cases（9eyes） of patients clinically diagnosed as the ARMD were included in this study,average response densities of 5-ring retinal regions before and 100 days after lutein and zeaxanthin treatmant were determined and compared.5 rings were recorded by 1 ring（2.18°）,2 ring （7.46°）,3 ring （12.36°）,4 ring（19.66°）,and 5 ring （29.75°） separately.All the data were analyzed by the Two Independent Samples t test of the software EPi Info for medical use.Results According to the examination result of mf-ERG,statistically analyzed the average response densities between post-treatment and Prior-treatment group by 1 ring（2.18°）,2 ring（7.46°）,3ring（12.36°）,4 ring（19.66°）,and 5 ring（29.75°） separately.The result was that the b values by amplitudes of the 5 rings between post-treatment and prior-treatment：each had significant difference （P〈0.05）.Conch-sions Lutein and zeaxanthin has the treatment effect and can improve the retinal function for age-related macular degeneration demonstrated by mf-ERG recordings.

关 键 词：多焦视网膜电图 叶黄素 玉米黄质 年龄相关性黄斑变性 

分 类 号：R774.5[医药卫生—眼科]