遗传性痉挛性截瘫伴薄胼胝体的影像学表现  

The imaging characteristics of hereditary spastic paraplegia with thin corpus callosum

作　　者：李晓东[1] 高佩虹[2] 王贵宾[2] 车峰远[2] 王金亮[2] 高乃永[2] 王桂玲[2] 

机构地区：[1]天津医科大学总医院放射科,天津300052 [2]山东省临沂市人民医院,山东临沂276003

出　　处：《中国临床医学影像杂志》2010年第7期465-468,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:分析遗传性痉挛性截瘫伴薄胼胝体(HSP-TCC)的影像学特点,以提高对此病的认识。方法:结合文献复习并报告一家族3例HSP-TCC患者的影像学表现。结果:本组3例HSP-TCC患者均显示胼胝体菲薄、颈胸髓明显变细,内见长T2信号、弥漫性非特异性脑白质病变和轻度脑萎缩。结论:HSP-TCC可广泛影响中枢神经系统,MRI特异性表现包括薄胼胝体,侧脑室周围白质长T2信号,脊髓萎缩及信号异常及后期出现轻度到中度脑萎缩。Objective： To analyze the imaging characteristics of hereditary spastic paraplegia with thin corpus callosum （HSP-TCC）, so as to get a better understanding of the disease. Methods： Three patients from the same family with HSP-TCC were reported with reviewing of the literature. Results： Thin corpus callosum, long T2 signal in the thinning cervical and thoracic spinal cord were seen. Diffused unspecific white matter lesions with mild brain atrophy, were also seen in the three HSP-TCC cases of this group. Conclusion： The central nervous system may be affected extensively by HSP-TCC, characteristic MRI signs including thin corpus callosum, long T2 signal in the white matter around lateral ventricle and in the spinal cord, atrophy and abnormal signal of the spinal cord, as well as subsequent mild or moderate brain atrophy.

关 键 词：痉挛性截瘫 遗传性 胼胝体 磁共振成像 

分 类 号：R746[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]