Role of neuregulin-1 in peripheral nerve injury  

作　　者：Zhengdong Kong Zhiying Zhang Haiyan Lin Chuansen Zhang 

机构地区：[1]Department of Anatomy, Second Military Medical University of Chinese PLA, Shanghai 200433, China

出　　处：《Neural Regeneration Research》2010年第14期1104-1108,共5页中国神经再生研究（英文版）

基　　金：a Grant from Science and Technology Commission of Shanghai,No.06ZR14108

摘　　要：Peripheral nerve injury in humans often leads to permanent functional deficits. Schwann cells play an important role in the recovery of peripheral nerve injury by ensheathing axons and providing various neurotrophic factors. Neuregulin-1 （NRG-1） provides axonal signals, which allow dedifferentiation and rapid proliferation of Schwann cells. Subsequently, NRG-1 promotes axonal myelination and influences myelin thickness. Moreover, NRG-1 plays a critical role in synapse formation in the neuromuscular junction. These effects, together, suggest that NRG-1 promotes recovery of peripheral nerve injury.Peripheral nerve injury in humans often leads to permanent functional deficits. Schwann cells play an important role in the recovery of peripheral nerve injury by ensheathing axons and providing various neurotrophic factors. Neuregulin-1 （NRG-1） provides axonal signals, which allow dedifferentiation and rapid proliferation of Schwann cells. Subsequently, NRG-1 promotes axonal myelination and influences myelin thickness. Moreover, NRG-1 plays a critical role in synapse formation in the neuromuscular junction. These effects, together, suggest that NRG-1 promotes recovery of peripheral nerve injury.

关 键 词：NEUREGULIN-1 nerve injury neurotrophic factors NEUROREGENERATION peripheral nerve Schwann cells MYELINATION REVIEW 

分 类 号：Q421[生物学—神经生物学] S831.1[生物学—生理学]