Inhibitory role of oxytocin in psychostimulant- induced psychological dependence and its effects on dopaminergic and glutaminergic transmission  

作　　者：Jing-yu YANG Jia QI Wen-yan HAN Fang WANG Chun-fu WU 

机构地区：[1]Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China [2]National Institute of Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA

出　　处：《Acta Pharmacologica Sinica》2010年第9期1071-1074,共4页中国药理学报（英文版）

摘　　要：Psychostimulants are frequently abused as a result of their stimulatory effects on several neurotransmitter systems within the central nervous system. Both dopaminergic and glutaminergic neurotransmissions have been closely associated with psychostimulant dependence. In addition to its classical endocrine function in the periphery, oxytocin, an important neurohypophyseal neuropeptide in the central nervous system, has a wide range of behavioral effects, including regulating drug abuse. The present paper reviews the progress of research into the role of oxytocin in reducing psychostimulant-induced psychological dependence and the mechanisms by which oxytocin mediates its effects.Psychostimulants are frequently abused as a result of their stimulatory effects on several neurotransmitter systems within the central nervous system. Both dopaminergic and glutaminergic neurotransmissions have been closely associated with psychostimulant dependence. In addition to its classical endocrine function in the periphery, oxytocin, an important neurohypophyseal neuropeptide in the central nervous system, has a wide range of behavioral effects, including regulating drug abuse. The present paper reviews the progress of research into the role of oxytocin in reducing psychostimulant-induced psychological dependence and the mechanisms by which oxytocin mediates its effects.

关 键 词：PSYCHOSTIMULANTS OXYTOCIN COCAINE METHAMPHETAMINE doPamine glulamate 

分 类 号：Q42[生物学—神经生物学] S858.237.2[生物学—生理学]