家族性胰腺癌的研究进展  

Advances in Study on Familial Pancreatic Cancer

作　　者：蒋荷[1] 王立夫[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院消化内科,200025

出　　处：《胃肠病学》2010年第9期565-567,共3页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(No.30971130)资助

摘　　要：家族性胰腺癌约占胰腺癌的10%,目前仍缺乏高敏感性和特异性的血清学标记物和其他诊断方法筛查家族性胰腺癌。近年随着分子遗传学的发展,发现一些癌基因和抑癌基因在胰腺癌发病中起重要作用。对家族性胰腺癌相关遗传性疾病的研究有助于发现胰腺癌的高危人群。本文就家族性胰腺癌的研究进展作一综述。Familial pancreatic cancer （FPC） accounts for approximately 10% of pancreatic cancer. Currently, there are no ideal biomarkers or other modalities with high sensitivity and specificity for screening FPC. With the development of molecular genetics, some oneogenes and tumor suppressor genes were found to play important roles in the pathogenesis of FPC, and the studies on FPC-related genetic diseases may contribute to the screening of high risk population for pancreatic cancer. This article reviewed the advances in study on FPC.

关 键 词：家族性胰腺癌 突变 肿瘤综合征 遗传性 分子生物学 

分 类 号：R735.9[医药卫生—肿瘤]