蛹虫草对D-半乳糖致衰老小鼠脑、肝组织氧化酶的影响  

Effect of Cordyceps militaris on Oxidases in Brain and Liver Tissues of D-Galactose-induced Senile Mice

作　　者：杨占军[1] 张健[1] 汤阳[1] 温鲁[1] 

机构地区：[1]淮阴师范学院生命科学院,江苏淮安223300

出　　处：《食品科学》2010年第19期339-341,共3页Food Science

基　　金：江苏省高校自然科学基金项目(05KJB180010);淮阴师范学院教授基金项目(06HSJS027)

摘　　要：目的:以衰老相关酶为指标,探讨蛹虫草对D-半乳糖致衰老小鼠的影响。方法:使用D-半乳糖建立小鼠衰老模型,用蛹虫草灌胃进行实验性治疗。持续6周后,测定脑和肝组织的总抗氧化能力(T-AOC)、谷胱甘肽过氧化物酶(GSH-Px)、单胺氧化酶(MAO)活性和丙二醛(MDA)含量。结果:与对照组相比,模型组小鼠的T-AOC、GSH-Px活性降低,MAO活性和MDA含量升高(P<0.05或P<0.01),说明造模成功;与模型组相比,蛹虫草组的T-AOC、GSH-Px活性有不同程度地恢复,MAO活性和MDA含量降低(P<0.05)。结论:蛹虫草可提高小鼠脑、肝组织的抗氧化能力。Objective：The enzymes related to aging were used as the indexes to explore the effect of Cordyceps militaris on D-galactose-induced senile mice. Methods：A mouse model with senile disturbance of brain tissue was established by D-galactose induction and the experimental mice were treated with Cordyceps militaris by gavage. After the administration of Cordyceps militaris for six weeks,the activities of T-AOC,GSH-Px,MAO and the content of MDA in brain and liver tissues were analyzed. Results：Compared with the control group,the activities of T-AOC and GSH-Px of the model group exhibited an obvious decrease,and the activity of MAO and the content of MDA exhibited a significant increase （P 〈0.05 or P〈 0.01）. Compared with the model group,the activities of T-AOC and GSH-Px in mice administered with Cordyceps militaris was ameliorated,and the activity of MAO and the content of MDA exhibited an obvious decrease （P〈 0.05）. Conclusion：Cordyceps militaris can improve the antioxidant capability of brain and liver tissues.

关 键 词：蛹虫草 D-半乳糖 衰老 氧化酶 

分 类 号：TQ929.2[轻工技术与工程—发酵工程]