Kringle5基因工程制备方法的研究进展  

Progress in Research on Gene Engineering Method for Preparation of Kringle 5

作　　者：陈显久[1] 牛勃[1] 赵荣瑞[1] 

机构地区：[1]山西医科大学,太原030001

出　　处：《中国生物制品学杂志》2011年第1期121-123,共3页Chinese Journal of Biologicals

基　　金：山西省科技攻关项目(20080321078);山西医科大学博士启动基金(03200823)

摘　　要：Kringle5是血浆纤维蛋白溶酶原的第5个饼环区结构,在体外具有抑制内皮细胞增殖、迁移的生物学活性,在体内可抑制多种血管新生模型的新生血管形成及肿瘤的生长和转移,在实体瘤、糖尿病视网膜病变、风湿性关节炎等疾病的治疗中具有广阔的应用前景。本文对国内外采用基因工程方法制备Kringle5的研究进展作一综述,为Kringle5蛋白基因工程药物的开发提供参考。As the fifth kringle domain of plasminogen（Pgn）,Kringle5 inhibits the proliferation and migration of endothelial cells in vitro,and the angiogenesis of several vascular neogenesis models as well as growth and metachoresis of tumor in vivo,which has a broad prospect of application in the therapy of some diseases such as solid tumor,pathological change of retina caused by diabetes and rheumatic arthritis. The progress in research on the gene engineering method for preparation of Kringle5 is reviewed in this paper,which provides a reference for the development of recombinant Kringle5 as a drug.

关 键 词：KRINGLE5 血浆纤维蛋白溶酶原 基因工程 

分 类 号：Q789[生物学—分子生物学] R730.23[医药卫生—肿瘤]