初筛合格供精者核型分析的临床意义探讨  

Karyotype analysis of qualified sperm donors on preliminary screening

作　　者：聂洪川[1,2] 谭跃球[1,2] 卢光琇[1,2] 

机构地区：[1]中南大学生殖与干细胞工程研究所 [2]中信湘雅生殖与遗传专科医院人类精子库,湖南长沙410078

出　　处：《中华男科学杂志》2011年第1期13-16,共4页National Journal of Andrology

基　　金：国家"973"计划项目(2007CB948103)~~

摘　　要：目的:探讨核型分析对于供精者筛选的作用。方法:2004年1月1日至2008年12月31日经过初步筛查合格的供精者2537例,抽取外周血进行常规核型分析。追踪合格供精者进行供精人工授精治疗后的临床妊娠及出生缺陷情况。结果:2537例初筛合格供精者中,发现2362例核型为46,XY,135例染色体核型有多态性,这两类初筛供精者均作为合格供精者。同时发现6例染色体异常,34例有争议的异常核型。结论:核型分析降低了供精人工授精受者妊娠染色体病患儿的风险,对于初筛供精者核型分析中发现的异常核型进行遗传咨询,有助于指导其未来的生育。Objective：To explore the significance of karotype analysis in screening sperm donors.Methods：From January 1,2004 to December 31,2008,a total of 2 537 potential sperm donors passed our preliminary screening,and all were routinely karyotyped via peripheral blood.Follow-ups were conducted on the pregnancy outcome and congenital malformation after artificial insemination with the sperm from the qualified donors.Results：Among the 2 537 qualified sperm donors,2 362 were of the normal karyotype 46,XY and 135 showed polymorphism.Abnormal karyotype was found in 6 cases,and controversial abnormal karyotype in 34.Conclusion：Karyotype analysis can reduce the risk of chromosomal disease in neonates from artificial insemination,and genetic counseling for abnormal karyotype sperm donors may help them solve their future reproductive problems.

关 键 词：供精者 染色体分析 染色体多态 染色体异常 

分 类 号：R698.2[医药卫生—泌尿科学]