家蚕蛹油对大鼠肝脏脂质代谢及相关酶活性的影响  

Effect of Silkworm Pupal Oil on Hepatic Lipid Metabolism and Related Lipase Activity in Rats

作　　者：黄静[1,2] 廖爱美[2,3] 潘文娟[2] 张海祥[2] 魏兆军[2] 

机构地区：[1]合肥工业大学医院,安徽合肥230009 [2]合肥工业大学生物与食品工程学院,安徽合肥230009 [3]合肥师范学院生命科学系,安徽合肥230061

出　　处：《食品科学》2011年第5期273-276,共4页Food Science

基　　金：安徽省"十一五"科技攻关项目(08010302149);江苏省科技支撑计划项目(农业BE2009365);教育部新世纪优秀人才基金项目(NCET-07-0251)

摘　　要：以不饱和脂肪酸含量达68%的家蚕蛹油为原料,喂食正常大鼠和高脂模型大鼠,检测大鼠肝脏总胆固醇、甘油三酯、高密度脂蛋白胆固醇、丙二醛浓度及脂蛋白脂酶和肝脂酶活性,研究蚕蛹油对大鼠肝脏脂质代谢及其相关酶活性的影响。结果表明:家蚕蛹油能显著降低大鼠肝脏组织总胆固醇、甘油三酯的含量,增加高密度脂蛋白胆固醇含量,降低肝脏致动脉粥样硬化指数和脂质过氧化产物丙二醛含量;显著提高脂蛋白脂酶和肝脂酶活性。上述结果说明家蚕蛹油具有调节大鼠肝脏脂质代谢、降低血脂的功效。Silkworm pupae oil extracted from the waste after silk reeling by supercritical carbon dioxide fluid extraction,which was found to contain 68% of unsaturated fatty acids,was administered intragastrically to normal rats and high fat model rats for 6 successive weeks and then fasted for 12 h after the last administration.The levels of hepatic total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein-cholesterol（HDL-C） and malonyldialdehyde（MDA） and the activities of related lipases such as lipoprotein lipase（LPL） and hepatic lipase（HL） were measured to clarify the effect of silkworm pupae oil on hepatic lipid metabolism and related lipase activity in rats.The results showed that silkworm pupae oil could significantly reduce the levels of hepatic TC and TG,increase HDL-C level,decrease atherosclerotic index and MDA level,and notably improve the activities of LPL and HL.It could be concluded from these results that silkworm pupae oil is capable of regulating lipid metabolism and decreasing blood lipid in rats.

关 键 词：家蚕蛹油 肝脏 总胆固醇 甘油三酯 脂蛋白脂酶 肝脂酶 脂质代谢 

分 类 号：R284.1[医药卫生—中药学]