沙棘油-聚乳酸羟基乙酸缓释微球的制备工艺  

PREPARATION OF SEA BUCKTHORN OIL-POLY (LACTIC-CO-GLYCOLIC ACID) SUSTAINED-RELEASE MICROSPHERES

作　　者：李崇达[1] 刘国琴[1,2] 李琳[1,2] 韩立娟[2] 

机构地区：[1]河南工业大学粮油食品学院,河南郑州450052 [2]华南理工大学轻工与食品学院,广东广州510640

出　　处：《河南工业大学学报（自然科学版）》2010年第6期45-49,共5页Journal of Henan University of Technology：Natural Science Edition

基　　金：国家自然科学基金(20976036);河南省杰出人才基金(074200510008);河南省科技攻关基金(072102270023)

摘　　要：以聚乙烯醇(PVA)为乳化剂、二氯甲烷和乙酸乙酯混合液为油相,通过超声辅助乳化溶剂挥发法制备沙棘油-聚乳酸羟基乙酸(PLGA)缓释微球.以微球综合质量指标(S值)为标准,探讨了PVA的质量浓度、芯材比(W/W)、超声功率和超声时间等因素对微球质量的影响.通过正交试验确定最佳工艺条件为:PVA质量浓度0.125 g/mL,芯材比8∶5,超声时间10 min,超声功率180 W,在此条件下制备的微球表面平滑、球形圆整、包埋效果好.The paper prepared the sea buckthorn oil-poly（lactic-co-glycolic acid） （PLGA） sustained-release micropheres by ultrasonic-assisted emulsion-solvent evaporation method using polyvinyl alcohol（PVA） as the emulsifier and using the mixture of dichloromethane and ethyl acetate as the oil phase.Taking the comprehensive quality index（S value） of the microsphere as the index,the paper also studied the effects of the mass concentration of PVA,the mass ratio of sea buckthorn oil to PLGA,the ultrasonic power and the ultrasonic time on the microsphere quality.Through the orthogonal tests,we determined the optimal conditions as follows： the mass concentration of PVA 0.125 g·mL-1,the mass ratio of sea buckthorn oil to PLGA 8∶5, ultrasonic time 10 minutes and ultrasonic power 180 W.The microspheres prepared under the optimal conditions had the advantages of smooth surface,good spherical shape and good encapsulation effect.

关 键 词：沙棘油 PLGA 微球 综合质量指标 

分 类 号：TS201.2[轻工技术与工程—食品科学]