白萝卜提取物对大鼠非酒精性脂肪肝的药效作用  

Effect of White Radish Extract on Nonalcoholic Fatty Liver Diseases in SD Rats

作　　者：由宏[1] 郝睿[1] 赵功玲[2] 朱本忠[1] 朱毅[1] 罗云波[1] 

机构地区：[1]中国农业大学食品科学与工程学院,北京100083 [2]河南科技学院食品学院,河南新乡453003

出　　处：《食品科学》2011年第7期300-304,共5页Food Science

基　　金：中央高校基本科研业务费专项资金项目(2009-1-86)

摘　　要：研究白萝卜提取物对大鼠非酒精性脂肪肝病的影响。实验用白萝卜提取物采用旋转蒸发的方法制备,使用脂肪乳剂灌胃法进行造模,设置低、中、高3个剂量处理组,分别以0.3、1、3mL/kg的剂量对SD大鼠进行灌胃。实验8周后观察各组大鼠的肝部组织病理学特点,并对血清中的脂类以及脂质过氧化相关酶类进行检测。结果显示:与模型组相比,雄性高剂量处理组大鼠血清甘油三酯(TG)以及丙二醛(MDA)水平明显降低,而还原性谷胱甘肽(GSH)明显增高。此外,肝脏病理切片显示白萝卜提取物有助于缓解脂肪在雄性大鼠肝中的积聚,而雌性大鼠的相关指标并无显著性差异。因此,白萝卜提取物可降低雄性非酒精性脂肪肝大鼠体内的脂质过氧化程度,从而起到延缓其非酒精性脂肪肝发展的作用。In order to exploit the medicinal value of white radish,the effect of white radish extract on the amelioration of nonalcoholic fatty liver diseases in SD rats was explored.The white radish extract was prepared with a rotary evaporator.The rats in model group were treated with fat emulsion with white radish extract by gavage at the doses of 0.3,1 mL/kg and 3 mL/kg.The pathological characteristics of liver tissues in rats with 8 weeks experiments were analyzed.Meanwhile,serum lipid and lipid peroxidases were determined.The results indicated that white radish extract at a high dose could significantly decrease the levels of serum TG and MDA and increase the levels of GSH in male rats.Moreover,white radish extract could alleviate the accumulation of lipid in the hepatocytes of male rats.However,no obvious change of these parameters in female rats was observed.Therefore,white radish extract can ameliorate nonalcoholic fatty liver diseases in SD male rats by decreasing the level of lipid peroxidation.

关 键 词：非酒精性脂肪肝 白萝卜提取物 病理学诊断 

分 类 号：R151.3[医药卫生—营养与食品卫生学]