乳酸菌抗肿瘤作用的研究进展  

Research Progress on Anti-tumor Activity of Lactic Acid Bacteria

作　　者：袁起伟[1] 郝凤奇[2] 杨文涛[1] 杨桂连[1] 王春凤[1] 

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130118 [2]长春理工大学生命科学技术学院,吉林长春130022

出　　处：《食品科学》2011年第9期303-306,共4页Food Science

基　　金：国家"863"计划项目(2006AA10A205;2007AA10Z322);国家自然科学基金项目(30671573;30700602;30870116);吉林省科技发展计划项目(20080104)

摘　　要：乳酸菌是人体消化道内正常菌群之一,已在世界范围内被认为是"GRAS(generally regarded as safe)"等级的食品微生物。乳酸菌通过阻止有害菌的定植与侵袭、激活机体抗肿瘤免疫系统、干扰肿瘤细胞代谢促进其凋亡等多种功能对多种肿瘤有预防与治疗作用。研究乳酸菌的抗肿瘤作用对肿瘤生物防治技术的进步和加快抗肿瘤药物的升级换代具有重要意义。The gastrointestinal tract is a complex environment with a diverse microbial community and the probiotic lactic acid bacteria is among the normal flora.Probiotics have been shown to promote the intestinal barrier function and immune responses and to interfere with metabolism of tumor cells,preventing and treating a variety of cancers.The development of biological agents of lactic acid bacteria with the effect of anti-tumor is the foundation of enhancing the biological anti-cancer technology and accelerating the drug upgrading for cancer treatment.

关 键 词：乳酸菌 抗肿瘤 抗肿瘤药物 

分 类 号：Q939.11[生物学—微生物学] R730.1[医药卫生—肿瘤]