家族性胰腺癌研究进展  

Advances in familial pancreatic cancer

作　　者：董锐增[1] 郭剑民[1] 

机构地区：[1]浙江省肿瘤医院腹部外科,杭州310022

出　　处：《国际肿瘤学杂志》2011年第4期292-295,共4页Journal of International Oncology

摘　　要：家族性胰腺癌是已确定的遗传性肿瘤综合征，为常染色体显性遗传，占全部胰腺癌3％左右。随着分子遗传学的发展，研究发现乳腺癌易感基因2、Palladin、周期素依赖激酶抑制因子2A等基因与家族性胰腺癌的发生有关，其中的一些基因突变已被确定为特定的肿瘤综合征的遗传基础。通过对高危人群监测可以在无症状时发现早期胰腺癌或胰腺癌前病变。Familial pancreatic cancer is a known hereditary cancer syndrome with autosomal dominant inheritance and accounts for about 3% of all pancreatic cancers. With the development of molecular genetics, several genes have been identified related with the familial pancreatic cancer, including breast cancer suscepti- bility gene 2, Palladin, cyclin-dependent kinase inhibitor 2A, et al. In particular, mutations in some of these genes have been defined as the hereditary basis of particular cancer syndromes. Molecular genetics surveillance for high risk populace can lead to the diagnosis of asymptomatic, early-stage pancreatic cancer or precancerous lesions.

关 键 词：胰腺肿瘤 家族性 肿瘤综合征 遗传性 监测 

分 类 号：R735.9[医药卫生—肿瘤]