Differential effects of aging on EEG after baclofen administration  

作　　者：FU Yu CUI JunHui MA YuanYe 

机构地区：[1]Department of Electronic Engineering, Information School, Yunnan University, Kunming 650091, China [2]State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

出　　处：《Science China(Life Sciences)》2011年第5期459-465,共7页中国科学（生命科学英文版）

基　　金：supported by grants from the Training Program for Young Backbone Teachers of Yunnan University,the Research Foundation of Yunnan University (Grant No.2008YB007);the Science Foundation of the Education Department of Yunnan (Grant No.09Y0034);the Special Fund of the "211" Third Phase Project of Yunnan University (Grant No.21134018);the National College Student Innovation Experiment Program (Grant No.101067312)

摘　　要：Baclofen is a selective gamma-aminobutyric acid (GABA) type B agonist that may have important medicinal uses,such as in analgesics and drug addiction treatment.In addition,evidence is accumulating that suggests GABAergic-mediated neurotransmission is altered during aging.This study investigated whether baclofen administration (5 mg kg 1) induces differential effects on cortical electrical activity with age.Electroencephalograms (EEGs) were recorded from young (3-4 months) and aged (15-17 months) rats,and both the absolute and relative powers in five frequency bands (delta:2-4 Hz;theta:4-8 Hz;alpha:8-12 Hz;beta:12-20 Hz;gamma:20-100 Hz) were analyzed.Before administration of baclofen,we found that the EEG relative power in the beta band was higher in the aged than that in the young rats.After administration of baclofen,there was a slower increase in the relative power in the delta band in the aged than that in the young rats.Moreover,there was no significant difference between the two age groups in absolute power in any frequency band.These findings indicate that baclofen treatment appears to differentially modify cortical EEG activity as a function of age.Our data further elucidate the relationship between GABA B receptor-mediated neurotransmission and aging.Baclofen is a selective gamma-aminobutyric acid （GABA） type B agonist that may have important medicinal uses, such as in analgesics and drug addiction treatment. In addition, evidence is accumulating that suggests GABAergic-mediated neurotransmission is altered during aging. This study investigated whether baclofen administration （5 mg kg-1） induces differential effects on cortical electrical activity with age. Electroencephalograms （EEGs） were recorded from young （3--4 months） and aged （15-17 months） rats, and both the absolute and relative powers in five frequency bands （delta： 2-4 Hz; theta： 4-8 Hz; alpha： 8-12 Hz; beta： 12-20 Hz; gamma： 20-100 Hz） were analyzed. Before administration of baclofen, we found that the EEG relative power in the beta band was higher in the aged than that in the young rats. After administration of baclofen, there was a slower increase in the relative power in the delta band in the aged than that in the young rats. Moreover, there was no significant difference between the two age groups in absolute power in any frequency band. These findings indicate that baclofen treatment appears to differentially modify cortical EEG activity as a function of age. Our data further elucidate the relationship between GABAB receptor-mediated neurotransmission and aging.

关 键 词：AGING BACLOFEN EEG spectra power rat 

分 类 号：Q42[生物学—神经生物学] TH772[生物学—生理学]