Phenibut(β-phenyl-γ-aminobutyric acid)is a psychoactive gamma-aminobutyric acid(GABA)analog marketed online as a nutritional and nootropic(cognition enhancing)supplement.Phenibut consumption poses a high risk of pot...
the Research Grant for Young Talented Scholars,National Research Council of Thailand,No.N41A640108.
BACKGROUND The association between diabetes mellitus(DM)and the increased risk and progression of cholangiocarcinoma(CCA)has been reported with unclear underlying mechanisms.Previous studies showed thatγ-aminobutyric...
BACKGROUND Persistent hiccups,lasting more than 48 h,have been described as an atypical presentation of coronavirus disease 19(COVID-19)in the general population.To the best of our knowledge,this is the first report o...
Acknowledgements This work was supported in part by grants-in-aid for scientific research from the National Basic Research Program of China (No 2015CB856401), the National Natural Science Foundation of China (No 31530035, 31571103, 81420108015, 31471064, 31421091, 81171255, and 31271164), the Shanghai Committee of Science and Technology (No 14JC1400900 and 13dz2260700), and the Key Laboratory Program of the Education Commission of Shanghai Municipality (No ZDSYS14005).
Aim: Ethanol, one of the most frequently used and abused substances in our society, has a profound impact on sedation. However, the neuronal mechanisms underlying its sedative effect remain unclear. In this study, we...
Aim To investigate the mechanisms underlying depressive-like behavior induced by chronic cerebral is- chemia in rats. Methods In the present study, a chronic cerebral hypoperfusion model was established by perma- 2VO...
Severe alcoholic hepatitis(AH)is an acute form of alcohol induced liver disease with a poor prognosis that is seen in the patients who consume large quantities of alcohol.The diagnosis of AH is based on the appropriat...
Supported by National Natural Science Foundation of China, No. 81170079;Shanghai Shenkang Hospital Development Center Project, No. SHDC12012211
AIM:To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy. METHODS:Sixteen patients with refracto...
Parkinson’s disease (PD) is characterized by degeneration of nigrostriatal dopamine (DA) neurons. The primary drug used to treat PD symptoms is L-DOPA, but side effects such as dyskinesias limit its use. Previous fin...