BACLOFEN

作品数:31被引量:104H指数:5
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相关领域:医药卫生更多>>
相关作者:刘根林汪家琮周红俊李之望司军强更多>>
相关机构:首都医科大学华中科技大学第二军医大学第四军医大学更多>>
相关期刊:《临床神经外科杂志》《Neuroscience & Medicine》《Journal of Behavioral and Brain Science》《Science China(Life Sciences)》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划江苏省卫生厅科技计划资助项目江苏省自然科学基金更多>>
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A case of phenibut withdrawal and treatment with baclofen
《World Journal of Emergency Medicine》2023年第4期338-340,共3页Michael Morris James Espinosa Alan Lucerna Robin Lahr 
Phenibut(β-phenyl-γ-aminobutyric acid)is a psychoactive gamma-aminobutyric acid(GABA)analog marketed online as a nutritional and nootropic(cognition enhancing)supplement.Phenibut consumption poses a high risk of pot...
关键词:treatment WITHDRAWAL ALCOHOL 
γ-aminobutyric acid B2 receptor:A potential therapeutic target for cholangiocarcinoma in patients with diabetes mellitus被引量:1
《World Journal of Gastroenterology》2023年第28期4416-4432,共17页Charupong Saengboonmee Supannika Sorin Sakkarn Sangkhamanon Surang Chomphoo Somsiri Indramanee Wunchana Seubwai Kanyarat Thithuan Ching-Feng Chiu Seiji Okada Marie-Claude Gingras Sopit Wongkham 
the Research Grant for Young Talented Scholars,National Research Council of Thailand,No.N41A640108.
BACKGROUND The association between diabetes mellitus(DM)and the increased risk and progression of cholangiocarcinoma(CCA)has been reported with unclear underlying mechanisms.Previous studies showed thatγ-aminobutyric...
关键词:BACLOFEN CHOLANGIOCARCINOMA Diabetes mellitus Drug repurposing HYPERGLYCEMIA Gamma-aminobutyric acid 
COVID-19 presenting with persistent hiccup and myocardial infarction in a peritoneal dialysis patient:A case report
《World Journal of Virology》2022年第4期198-203,共6页Dimitra Bacharaki Panagiotis Giannakopoulos Konstantinos Markakis Christos Papas Aikaterini Theodorou Vasiliki Zoi Georgios Tsivgoulis Sophia Lionaki 
BACKGROUND Persistent hiccups,lasting more than 48 h,have been described as an atypical presentation of coronavirus disease 19(COVID-19)in the general population.To the best of our knowledge,this is the first report o...
关键词:COVID-19 Peritoneal dialysis Atypical presentation HICCUP Myocardial infarction BACLOFEN Case report 
Comparison of Baclofen and Tizanidine in Reducing Spasticity in Cerebral Palsy: A Randomized Control Trial被引量:1
《Open Journal of Pediatrics》2020年第4期617-625,共9页Nazmul Haque Narayan Saha Tahmina Ahmed Bithi Debnath Abid Hossain Mollah Ekhlasur Rahman 
Background: Cerebral palsy is the most common chronic motor disability that begins in childhood...
关键词:Cerebral Palsy SPASTICITY BACLOFEN TIZANIDINE 
Ethanol inhibits histaminergic neurons in mouse tuberomammillary nucleus slices via potentiating GABAergic transmission onto the neurons at both pre- and postsynaptic sites
《Acta Pharmacologica Sinica》2016年第10期1325-1336,共12页Yu SUN Shi-yu JIANG Jian NI Yan-jia LUO Chang-rui CHEN Zong-yuan HONG Yuchio YANAGAWA Wei-min QU Lu WANG Zhi-li HUANG 
Acknowledgements This work was supported in part by grants-in-aid for scientific research from the National Basic Research Program of China (No 2015CB856401), the National Natural Science Foundation of China (No 31530035, 31571103, 81420108015, 31471064, 31421091, 81171255, and 31271164), the Shanghai Committee of Science and Technology (No 14JC1400900 and 13dz2260700), and the Key Laboratory Program of the Education Commission of Shanghai Municipality (No ZDSYS14005).
Aim: Ethanol, one of the most frequently used and abused substances in our society, has a profound impact on sedation. However, the neuronal mechanisms underlying its sedative effect remain unclear. In this study, we...
关键词:ETHANOL tuberomammillary nucleus histaminergic neurons GABA receptor IPSCs BICUCULLINE BACLOFEN TETRODOTOXIN 
Activation of GABAB receptors alleviates depressive-like behavior induced by chronic cerebral ischemia via upredulation of BDNF in rats
《中国药理学通报》2015年第B11期77-78,共2页
Aim To investigate the mechanisms underlying depressive-like behavior induced by chronic cerebral is- chemia in rats. Methods In the present study, a chronic cerebral hypoperfusion model was established by perma- 2VO...
关键词:GABAB RECEPTORS BACLOFEN depressive-like behavior chronic cerebral ISCHEMIA BDNF hippocampalCA1 
巴氯芬鞘内注射撤药症状的认识与处理被引量:5
《临床神经外科杂志》2014年第4期311-312,共2页张宇清 
肌强直是很多神经系统疾病的严重表现,常见于脑瘫、脑外伤、多发硬化、脊髓损伤、家族性痉挛性截瘫、脊髓肿瘤、横贯性脊髓炎、肌萎缩侧索硬化、神经纤维瘤病、红斑狼疮性脊髓炎等疾病。其特点是肌张力增高,腱反射亢进,病理征阳性,...
关键词:药物鞘内注射 撤药症状 巴氯芬 选择性脊神经后根切断术 美国食品和药物管理局 家族性痉挛性截瘫 BACLOFEN 神经系统疾病 
Pharmacotherapy of acute alcoholic hepatitis in clinical practice
《World Journal of Gastroenterology》2014年第9期2159-2167,共9页Ludovico Abenavoli Natasa Milic Samir Rouabhia Giovanni Addolorato 
Severe alcoholic hepatitis(AH)is an acute form of alcohol induced liver disease with a poor prognosis that is seen in the patients who consume large quantities of alcohol.The diagnosis of AH is based on the appropriat...
关键词:Severe alcoholic hepatitis  Maddrey’ s discriminant function  Glucocorticoids  Baclofen  Orthotopic liver transplantation  Alcoholic liver disease 
Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough被引量:20
《World Journal of Gastroenterology》2013年第27期4386-4392,共7页Xiang-Huai Xu Zhong-Min Yang Qiang Chen Li Yu Si-Wei Liang Han-Jing Lv Zhong-Min Qiu 
Supported by National Natural Science Foundation of China, No. 81170079;Shanghai Shenkang Hospital Development Center Project, No. SHDC12012211
AIM:To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy. METHODS:Sixteen patients with refracto...
关键词:BACLOFEN COUGH ESOPHAGEAL pH monitoring GASTROESOPHAGEAL REFLUX Proton pump inhibitors 
Dopamine and GABA Interaction in Basal Ganglia: GABA-A or GABA-B Receptor Stimulation Attenuates L-DOPA-Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
《Journal of Behavioral and Brain Science》2013年第6期479-488,共10页Sarah Lynch Subbiah P. Sivam 
Parkinson’s disease (PD) is characterized by degeneration of nigrostriatal dopamine (DA) neurons. The primary drug used to treat PD symptoms is L-DOPA, but side effects such as dyskinesias limit its use. Previous fin...
关键词:DOPAMINE ERK1/2 HEMIPARKINSONISM GABA Striatum Substantia Nigra MUSCIMOL BACLOFEN 
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