HEMIPARKINSONISM

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Dopamine and GABA Interaction in Basal Ganglia: GABA-A or GABA-B Receptor Stimulation Attenuates L-DOPA-Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
《Journal of Behavioral and Brain Science》2013年第6期479-488,共10页Sarah Lynch Subbiah P. Sivam 
Parkinson’s disease (PD) is characterized by degeneration of nigrostriatal dopamine (DA) neurons. The primary drug used to treat PD symptoms is L-DOPA, but side effects such as dyskinesias limit its use. Previous fin...
关键词：DOPAMINE ERK1/2 HEMIPARKINSONISM GABA Striatum Substantia Nigra MUSCIMOL BACLOFEN 
GABA Attenuates L-DOPA-Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
《Journal of Behavioral and Brain Science》2013年第3期320-330,共11页Sarah Lynch Subbiah P. Sivam 
L-DOPA is the primary drug used to treat Parkinson’s disease (PD) symptoms, but motor side effects limit its long term use. Previous experimental studies show that L-DOPA acts on supersensitive D1 receptors in the ba...
关键词：Dopamine ERK1/2 HEMIPARKINSONISM GABA STRIATUM Substantia Nigra 
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