BICUCULLINE

作品数：18被引量：27H指数：3
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相关作者：周晓明孙心德冯瑞本王绍张唯更多>>
相关机构：华东师范大学白求恩医科大学重庆三峡学院云南中医药大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《中国科技期刊数据库 医药》《北京生物医学工程》《Journal of Behavioral and Brain Science》更多>>
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健康成年小鼠和AD模型小鼠在GABA受体调节后脑电与记忆的不同相关模式被引量：1
《中山大学学报（自然科学版）（中英文）》2022年第3期11-20,共10页周正 李连娥 段梦思 孙华英 易虎 付玉 
国家自然科学基金(81760258,81560221,81703497,61972158);云南省自然科学基金(2017FB125,2017FD067)。
正常衰老和阿尔茨海默病(AD,Alzheimer′s disease)都与大脑萎缩、神经元丢失、神经递质紊乱以及认知退化有关,并且这些变化在AD中更为明显,进展更加快速。因此,有人提出了AD表现出加速衰老的这一假设。AD和正常衰老都涉及兴奋/抑制(E/I...
关键词：衰老加速 阿尔茨海默病(Alzheimer′s disease AD) BICUCULLINE GABA_(A) MUSCIMOL 空间记忆 
VTA区GABA A受体调控DA能神经元放电对小鼠抑郁样行为的影响
《中国科技期刊数据库 医药》2021年第8期185-186,共2页张丹旭 孙蕊 贺凌霄 黄锦怡 
探究腹侧被盖区(ventral tegmental area,VTA)GABAA受体的激活对小鼠抑郁样行为的影响。方法:c57/BL-6雄性小鼠VTA区置管给药,分别注射生理盐水、γ羟基丁酸(GABA)、muscimol(GABAA受体激动剂)、bicuculline(GABAA受体拮抗剂),测量小鼠...
关键词：GABA A受体 悬尾试验 MUSCIMOL BICUCULLINE 抑郁样行为 
GABA_A Receptor Activity Suppresses the Transition from Interictal to Ictal Epileptiform Discharges in Juvenile Mouse Hippocampus被引量：4
《Neuroscience Bulletin》2018年第6期1007-1016,共10页Yan-Yan Chang Xin-Wei Gong Hai-Qing Gong Pei-Ji Liang Pu-Ming Zhang Qin-Chi Lu 
supported by the Key Basic Research Project of Science and Technology Commission of Shanghai (13DJ1400303);the Shanghai Jiao Tong University Fund for Interdisciplinary Research for Medical Applications (YG2012ZD08);the Seed Fund of Ren Ji Hospital (RJ ZZ13-005)
Exploring the transition from inter-ictal to ictal epileptiform discharges(IDs) and how GABAAreceptormediated action affects the onset of IDs will enrich our understanding of epileptogenesis and epilepsy treatment.We ...
关键词：Epileptiform discharge Gamma-aminobutyric acid BICUCULLINE MUSCIMOL Micro-electrode array Hippocampal slice 
Ethanol inhibits histaminergic neurons in mouse tuberomammillary nucleus slices via potentiating GABAergic transmission onto the neurons at both pre- and postsynaptic sites
《Acta Pharmacologica Sinica》2016年第10期1325-1336,共12页Yu SUN Shi-yu JIANG Jian NI Yan-jia LUO Chang-rui CHEN Zong-yuan HONG Yuchio YANAGAWA Wei-min QU Lu WANG Zhi-li HUANG 
Acknowledgements This work was supported in part by grants-in-aid for scientific research from the National Basic Research Program of China （No 2015CB856401）, the National Natural Science Foundation of China （No 31530035, 31571103, 81420108015, 31471064, 31421091, 81171255, and 31271164）, the Shanghai Committee of Science and Technology （No 14JC1400900 and 13dz2260700）, and the Key Laboratory Program of the Education Commission of Shanghai Municipality （No ZDSYS14005）.
Aim： Ethanol, one of the most frequently used and abused substances in our society, has a profound impact on sedation. However, the neuronal mechanisms underlying its sedative effect remain unclear. In this study, we...
关键词：ETHANOL tuberomammillary nucleus histaminergic neurons GABA receptor IPSCs BICUCULLINE BACLOFEN TETRODOTOXIN 
Competitive antagonists facilitate the recovery from desensitization of α1β2Y2 GABAA receptors expressed in Xenopus oocytes被引量：2
《Acta Pharmacologica Sinica》2016年第8期1020-1030,共11页Xiao-jun XU Diane ROBERTS Guo-nian ZHU Yong-chang CHANG 
Aim： The continuous presence of an agonist drives its receptor into a refractory state, termed desensitization. In this study, we tested the hypothesis that a competitive antagonist, SR95531, could facilitate the rec...
关键词：GABAA receptor DESENSITIZATION GABA SR95531 BICUCULLINE Xenopus oocytes 
Kainic Acid, NMDA and Bicuculline Induce Elevation in Concentrations of Glutathione and Amino Acids <i>in Vivo</i>: Biomarkers for Seizure Predisposition?
《Journal of Behavioral and Brain Science》2015年第5期163-172,共10页Abdul-Karim Abbas 
The present study was carried out to investigate the effect of NMDA, bicuculline and kainic acid (KA) on the extracellular concentration of glutathione, phosphoethanolamine (PEA) and taurine in rat hippocampus in vivo...
关键词：NMDA GLUTATHIONE Taurine Hippocampus Microdialysis Kainic Acid SEIZURE 
Muscimol microinjection into cerebellar fastigial nucleus exacerbates stress-induced gastric mucosal damage in rats被引量：3
《Acta Pharmacologica Sinica》2013年第2期205-213,共9页Jin-zhou ZHU Suduan FEI Jian-fu ZHANG Sheng-ping ZHU Zhang-bo LIU Ting-ting LI XiaoQIAO 
Aim： To investigate the effects of microinjection of the GABAA receptor agonist muscimol into cerebellar fastigial nucleus （FN） on stress- induced gastric mucosal damage and the underlying mechanism in rats. Method...
关键词：CEREBELLUM fastigial nucleus decussation of superior cerebellar peduncle lateral hypothalamic area GABA MUSCIMOL BICUCULLINE gastric mucosa stress-induced gastric mucosal damage apoptosis 
GABA能抑制环路对神经元信噪比的调节作用
《北京生物医学工程》2013年第1期28-32,共5页刘治国 周保琢 梁振 周逸峰 
目的研究初级视皮层内抑制性环路与神经元反应信噪比之间的关系。方法通过胞外局部微电泳GABA及其受体拮抗剂Bicuculline改变神经元的抑制水平,并采用胞外单细胞技术记录神经元对视觉刺激所发放的动作电位。本文分析并比较了65个猫的初...
关键词：抑制 信噪比 GABA BICUCULLINE 衰老 
Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats被引量：4
《Acta Pharmacologica Sinica》2011年第12期1460-1465,共6页Bo YANG Ben-fu WANG Miao-jun LAI Fu-qiang ZHANG Xiao-wei YANG Wen-hua ZHOU Qing-quan LIAN 
Aim： Propofol has shown abuse potential. The aim of the present study is to investigate the effects of GABAA antagonist and GABAB agonist on propofol reinforcement. Methods： Sprague-Dawley rats were trained to self-...
关键词：addiction PROPOFOL drug abuse. GABA receptors BACLOFEN BICUCULLINE ventral tegmental area （VTA） locomotor activity 
Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2011年第11期900-908,共9页Lotfollah KHAJEHPOUR Acieh ALIZADEH-MAKVANDI Mahnaz KESMATI Hooman ESHAGH-HAROONI 
supported by the Shahid Chamran University of Ahvaz,Iran
In this study we investigated whether GABAA receptors of the basolateral amygdala(BLA) interact with the effect of dexamethasone on the retrieval stage of memory.Adult male Wistar rats were bilaterally cannulated in t...
关键词：Basolateral amygdala DEXAMETHASONE MUSCIMOL BICUCULLINE Passive avoidance task 
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