苹果提取物对小鼠脂肪代谢的影响  

Effect of apple extracts on mice lipid metabolism

作　　者：周丽萍[1] 王振宇[2,3] 刘瑜[2] 

机构地区：[1]黑龙江省科学院自然与生态研究所,黑龙江哈尔滨150040 [2]东北林业大学林学院,黑龙江哈尔滨150040 [3]哈尔滨工业大学食品科学与工程学院,黑龙江哈尔滨150001

出　　处：《食品工业科技》2011年第6期380-383,共4页Science and Technology of Food Industry

基　　金：东北林业大学研究生创新项目

摘　　要：目的:研究苹果提取物对小鼠脂肪代谢的调节作用。方法:将小鼠随机分为5组,除基础对照组外,其他4组给予高脂饲料,每周称体质量1次,建立高脂模型。基础对照组和模型对照组分别灌胃生理盐水(38mg/kg·bw),3个剂量组分别灌胃苹果提取物38、76、114mg/kg·bw。连续4周后,分别测定小鼠体质量、血清总胆固醇(TC)、血清总甘油三酯(TG)、高密度脂蛋白(HDL-C)、丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、肝脂酶(HL)和脂蛋白脂酶(LPL)活性。结果:苹果提取物能明显降低小鼠体质量、TG、TC、低密度脂蛋白(LDL-C)和MDA含量以及动脉粥样硬化指数(AI),对高脂小鼠血清中HDL-C有明显的升高作用,能有效提高小鼠体内SOD、GSH-PX、HL和LPL的活性。结论:苹果提取物可以通过调节脂肪代谢来降低血脂。Objective：To study the effect of apple extracts on lipid metabolism in mice.Method：60 mice were divided into 5 groups randomly.Except normal control group,the other four groups were fed high fat diet.Normal control and obesity control groups were fed i.g.normal saline,the other three groups were fed i.g.38,76 and 114g/kg·bw apple extracts.The mice were killed after 4 weeks,the mice body weight,the content of serum total triglycerides（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,malondialdehyde（MDA）,the activity of superoxide dismutase（SOD）,glutathione peroxidase（GSH-PX）,hepatic lipase（HL）and lipoprotein lipase（LPL）were assayed.Results：Apple extracts could obviously reduce the mice body weight,the content of TG,TC,low density lipoprotein cholesterol（LDL-C）and MDA,and atherosclerosisdisease index（AI）.It could also improve HDL-C and the activity of SOD,GSH-PX,HL and LPL in their blood serum.Conclusion：The apple extracts have the functions in reducing blood lipid by adjusting the lipid metabolism of mice.

关 键 词：苹果提取物 血脂 脂质过氧化 脂肪代谢 

分 类 号：TS201.4[轻工技术与工程—食品科学]