5-HTTVNTR与自杀未遂精神病核心家系的相关性研究  

Study of correlation of 5-HTTVNTR and nuclear family with psychotic disorder and suicide attempts

作　　者：甘窈[1] 高新学[2] 艾明[1] 陈建梅[1] 黎雪梅[1] 况利[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,400016 [2]山东省济宁市精神病防治院精神六科,272051

出　　处：《重庆医学》2011年第17期1685-1686,1688,共3页Chongqing medicine

基　　金：重庆市卫生局科研项目(07-2-049)

摘　　要：目的了解5-羟色胺转运体(5-HTT)基因第二内含子多态性(5-HTTVNTR)与有精神病的自杀未遂核心家系的相关性。方法应用聚合酶链反应(PCR)检测5-HTTVNTR,传递不平衡检验(TDT)分析自杀未遂精神病患者5-HTT基因的多态性位点。结果 5-HTTVNTR多态性位点与自杀未遂精神病患者不存在连锁不平衡(χ2=2.38,P>0.05)。结论 5-HTTVNTR多态性位点与自杀未遂精神病核心家系无明显相关性。Objective To explore the correlation of serotonin transporter gene 2 VNTR polymorphism（5-HTTVNTR） and nuclear family with psychotic disorder and suicide attempts.Methods Polymerase chain reaction（PCR） was employed to detect 5-HTTVNTR and transmission disequilibrium test（TDT） was used to analyze 5-HTT gene polymorphism in patients with psychotic disorder and attempted suicide.Results There was no linkage disequilibrium between 5-HTTVNTR and patients with psychotic disorder and suicide attempts（χ2=2.38,P0.05）.Conclusion There is no significant correlation between 5-HTTVNTR and nuclear family with psychotic disorder and suicide attempts.

关 键 词：自杀未遂 精神病 等位基因 多态现象 遗传 色胺类 

分 类 号：R749[医药卫生—神经病学与精神病学]