新型喹啉类蛋白酪氨酸激酶抑制剂的合成  

Design and Synthesis of Quinoline Derivatives as Protein Tyrosine Kinase Inhibitors

作　　者：史祥飞[1] 薛阳 赵砚瑾[1] 李庶心[1,3] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]总后勤部管理局第一门诊部,北京100842 [3]首都师范大学生命科学院,北京100048

出　　处：《解放军药学学报》2011年第3期189-192,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的设计合成一系列新型喹啉双芳基脲类化合物作为潜在的蛋白酪氨酸激酶抑制剂。方法以2甲-基-2苯基丙酸为原料经过9步反应,合成了12个喹啉衍生物,结构经过1H-NMR鉴定。结果合成的12个目标化合物,均未见文献报道。结论该合成方法简单易行,可作为一系列喹啉类蛋白酪氨酸激酶抑制剂的合成通法。Objective To synthesize novel quinoline derivatives as antitumor drug candidates.Methods 12 derivatives of quinoline were synthesized in nine steps from 2-methyl-2-phenylpropanoic acid.Their structures were identified by 1H-NMR.Results Twelve novel compounds were synthesized.Conclusion This method can be a general method to synthesize a series of novel quinoline derivatives as protein tyrosine kinase inhibitors.

关 键 词：肿瘤 蛋白酪氨酸激酶 蛋白酪氨酸激酶抑制剂 喹啉衍生物 合成 

分 类 号：R915.5[医药卫生—微生物与生化药学]