液质联用快速鉴定减肥类保健食品中4种违禁添加药物  

Rapid screening of 4 illegal additives in slimming food by LC-MS/MS

作　　者：杨路平[1] 王国玲[1] 焦燕妮[1] 

机构地区：[1]山东省疾病预防控制中心,山东济南250012

出　　处：《中国食品卫生杂志》2011年第4期320-321,共2页Chinese Journal of Food Hygiene

摘　　要：目的建立快速鉴定减肥类保健食品中咖啡因、盐酸麻黄碱、盐酸芬氟拉明和盐酸西布曲明的液质联用方法。方法使用Agilent 1100液相色谱和离子阱质谱联用,ESI源,C18柱梯度洗脱。结果使用本方法对12种市售减肥保健食品中的4种违禁添加药物进行了快速筛查鉴定,其中2种检出西布曲明。结论方法简便快速,专属性好。Objective To establish a LC-MS/MS method for the screening of 4 illegal additives in slimming food.Methods The target compounds were analyzed by Agilent 1100 HPLC and TRAP MSD with ESI source,C18 column with methanol-water（0.1% HAc） gradient elution was applied.Results Twelve slimming products were analyzed and sibutramine was detected in 2 products.Conclusion The method is rapid,specific and suitable for rapid screening for these 4 illegal additives in slimming products.

关 键 词：液质联用 违禁添加药物 咖啡因 盐酸麻黄碱 盐酸芬氟拉明 盐酸西布曲明 保健食品 食品安全 

分 类 号：R155.5[医药卫生—营养与食品卫生学]