系列海洋特征性寡糖抗紫外辐射构效关系研究  

Structure-function Relationship of Anti-ultraviolet Radiation in Series of Marine Derived Characteristic Oligosaccharides

作　　者：王鹏[1] 江晓路[1] 江艳华[2] 牟海津[1] 李蔓[1] 

机构地区：[1]中国海洋大学食品科学与工程学院,青岛266003 [2]中国水产科学研究院黄海水产研究所,青岛266071

出　　处：《天然产物研究与开发》2011年第5期874-877,904,共5页Natural Product Research and Development

基　　金：国家自然科学基金(30901122);国家科技支撑计划子课题(2007BAD62B03)

摘　　要：本文通过测定在紫外光胁迫下系列海洋特征性寡糖——褐藻寡糖、岩藻寡糖和壳寡糖分别对革兰氏阴性、阳性菌的抗辐射保护作用,并结合特征性寡糖的紫外吸收光谱及清除自由基能力初步探讨海洋活性寡糖抗紫外辐射作用机理及同分子量级海洋寡糖链间构效关系。结果表明三种活性寡糖均具有抗紫外线辐射作用,其效果与寡糖浓度呈正相关。三种海洋寡糖,抗辐射效果依次为褐藻寡糖>壳寡糖>岩藻糖。通过构效关系研究表明,抗辐射过程中特征性糖链的双键紫外吸收作用在细菌抗辐射保护过程中起主导作用,而特征性糖链的清除自由基能力具有辅助作用。The series of marine derived oligosaccharides, alginate oligosaccharides, fucose oligosaccharides and chitosan oligosaccharide were collected to analyze their protective effect of bacteria on the subject to ultraviolet radiation. Combined with the characteristic UV absorption spectra and free radical scavenging capacity, the study of marine oligosaccha- rides activity mechanism of anti-ultraviolet radiation was preliminary conducted. The results showed that marine derived oligosaccharides had anti-ultraviolet radiation abilities in varying degrees, having a positive correlation with the concentration of oligosaccharides. The order of three oligosaccharides anti-radiation effect is alginate oligosaccharides 〉 ehitosan oligosaecharide 〉 fucose oligosaccharides. Combined with the structure-activity relationship studies, we could primarily conclude that the effect of ultraviolet absorption of specific carbohydrates chains＇ unsaturated bond played a leading role in the process of UV radiation. In another aspect,the free radical scavenging ability of carbohydrates chain showed some supporting role during the UV process.

关 键 词：海洋寡糖 抗辐射 紫外吸收 清除自由基 

分 类 号：Q949.2[生物学—植物学] R142.2[医药卫生—公共卫生与预防医学]