microRNAs, an active and versatile group in cancers  

作　　者：Jeffrey Liu Min Zheng Ya-ling Tang Xin-hua Liang Qin Yang 

机构地区：[1]Department of Biological Sciences, University of Delaware, Nowak DE 19716, USA [2]State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China [3]Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China [4]Cancer Biology Division, School of Medicine, Washington University, St. Louis MO 63108, USA

出　　处：《International Journal of Oral Science》2011年第4期165-175,共11页国际口腔科学杂志（英文版）

基　　金：supported by National Natural Science Foundation of China grants (No. 30872889, 81072215, 81001210, 81172580);Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 20098-8-2);State Key Laboratory of Oral Diseases Open Funding (SKLODOF2010-05);the Fundamental Research Funds of the Central Universities of China (2011)

摘　　要：microRNAs （miRNAs） are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development, miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflam- mation, anti-cancer drug resistance, and regulation of cancer stem ceils. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.microRNAs （miRNAs） are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development, miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflam- mation, anti-cancer drug resistance, and regulation of cancer stem ceils. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.

关 键 词：MICRORNAS CANCER epithelial-mesenchymal transition INFLAMMATION cancer stem cells drug resistance 

分 类 号：R730.2[医药卫生—肿瘤]