不同处理的精制玉米麸皮对链脲佐菌素(STZ)诱导的糖尿病小鼠的降糖作用  

Hypoglycemic Effect of Refined Corn Bran with Different Treatments in STZ-induced Diabetic Mice

作　　者：李勤勤[1] 耿欣[1] 

机构地区：[1]青岛农业大学食品科学与工程学院,山东青岛266109

出　　处：《食品科学》2011年第19期236-239,共4页Food Science

摘　　要：目的:探讨不同处理的精制玉米麸皮对链脲佐菌素(STZ)所致糖尿病小鼠高血糖的预防作用。方法:对脱淀粉、蛋白后的精制玉米麸皮分别进行酸碱处理,得到相应的酸碱降解产物。分别以精制玉米麸皮(RCB组)、精致玉米麸皮酸解产物(HAC组)、精制玉米麸皮碱解产物(HAL组)为受试物添加到小鼠饲料中喂养21d后,除正常组外,小剂量多次腹腔注射STZ建立糖尿病小鼠模型。测定各组小鼠的体质量、采食量、血糖含量、体力活力及肝脏各相关指数。结果:与对照组相比,不同处理的精制玉米麸皮可显著减少由STZ诱导的糖尿病小鼠体质量的下降程度(P<0.05),并且可显著增加小鼠体力活力,延缓疲劳的发生;酸解产物可显著抑制由STZ诱导的糖尿病小鼠血糖含量的升高(P<0.05)及显著增加肝组织中GSH和SOD的含量(P<0.05),能极显著增加肝组织中糖原的水平(P<0.01)并能显著降低肝组织中MDA的含量(P<0.05)。结论:精制玉米麸皮的酸解产物有明显预防STZ诱导的糖尿病小鼠血糖升高、体质量减轻的作用,可能与其能提高糖尿病小鼠体内抗氧化水平及保护肝糖原水平有关。Objective： To explore the preventive effect of refined corn bran with different treatments on hyperglycemia in diabetic mice induced by streptozocin（STZ）.Methods： Refined corn bran（RCB） after removing starch and protein was treated by acid and alkali,respectively to obtain an acidic hydrolysate（HAC） and an alkaline hydrolysate（HAL）.After being fed standard diet alone or with the respective additions of RCB,HAC and HAL for 21 consecutive days,mice were subjected to multiple low-dose STZ injections for creating a diabetic mouse model except the normal group.The body weight,food intake,blood glucose,physical activity and liver index in each mouse were examined.Results： Compared with the control group,HAC and HAL could significantly suppress the reduction of body weight（P0.05）,increase physical activity,and delay fatigue in diabetic mice.In addition,HAC could significantly decrease blood glucose in the liver of diabetic mice（P0.05）,whereas,GSH and SOD levels were obviously increased.Moreover,HAC could also increase glycogen level remarkably and decrease MDA level in the liver.Conclusion： HAC can effectively prevent the increase of blood glucose and the reduction of body weight in STZ-induced diabetic mice and the mechanisms might be correlated to the increase of antioxidant activity and maintenance of liver glycogen in diabetic mice.

关 键 词：精制玉米麸皮酸碱降解产物 链脲佐菌素 糖尿病小鼠 血糖 预防 

分 类 号：TS210.9[轻工技术与工程—粮食、油脂及植物蛋白工程]