Deciphering tumor-suppressor signaling in flies:Genetic link between Scribble/Dlg/Lgl and the Hippo pathways  

作　　者：Masato Enomoto Tatsushi Igaki 

机构地区：[1]Department of Cell Biology,G-COE,Kobe University Graduate School of Medicine,7-5-1 Kusunoki-cho,Chuo-ku,Kobe 650-0017,Japan [2]Japan Science and Technology Agency,PRESTO,4-1-8 Honcho,Kawaguchi,Saitama 332-0012,Japan

出　　处：《Journal of Genetics and Genomics》2011年第10期461-470,共10页遗传学报（英文版）

摘　　要：Loss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression, scribbleldiscs largellethal giant larvae （scrib/dlg/lgl）, a group of apico-basal polarity genes, were initially identified as members of ＂neoplastic＂ tumor-suppressors in flies. The components of the Hippo signaling pathway, which is crucial for organ size control and cancer development, were also identified through Drosophila genetic screens as members of ＂hyperplastic＂ tumor-suppressors. Accumulating evidence in recent studies implies that these two tumor-suppressor signaling pathways are not mutually exclusive but rather cooperatively act to give rise to highly malignant tumors. The interaction of these tumor-suppressor pathways could include deregulations of actin cytoskeleton, cell-cell contact, and apical-domain size ofLoss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression, scribbleldiscs largellethal giant larvae （scrib/dlg/lgl）, a group of apico-basal polarity genes, were initially identified as members of ＂neoplastic＂ tumor-suppressors in flies. The components of the Hippo signaling pathway, which is crucial for organ size control and cancer development, were also identified through Drosophila genetic screens as members of ＂hyperplastic＂ tumor-suppressors. Accumulating evidence in recent studies implies that these two tumor-suppressor signaling pathways are not mutually exclusive but rather cooperatively act to give rise to highly malignant tumors. The interaction of these tumor-suppressor pathways could include deregulations of actin cytoskeleton, cell-cell contact, and apical-domain size of

关 键 词：Cell polarity Hippo pathway DROSOPHILA SCRIBBLE DLG lgl TUMOR-SUPPRESSOR Tumor progression 

分 类 号：R730.2[医药卫生—肿瘤]