微生物发酵琥珀酸的研究进展  

Research Progress on Succinic acid Production by Microbial Fermentation

作　　者：郑璞[1] 孙志浩[1] 倪晔[1] 刘璇[1] 

机构地区：[1]江南大学生物工程学院教育部工业生物技术重点实验室,无锡214122

出　　处：《生物技术通报》2008年第S1期95-101,共7页Biotechnology Bulletin

基　　金：国家863项目(No.2006AA02Z235);江苏省自然科学基金前期预研项目(No.BK2005201)

摘　　要：琥珀酸是一种重要的C_4平台化合物,生物基琥珀酸可作为合成大宗化学品的起始原料,在食品、医药、表面活性剂、洗涤剂、绿色溶剂、生物可降解塑料和动植物生长刺激物剂领域有广泛的应用前景。从可再生原料出发,发酵过程固定CO_2,使得微生物发酵生产琥珀酸具有良好的环境优势,成为近年研究的热点。围绕微生物发酵法生产琥珀酸迫切需要解决的主要问题,综述了国内外对琥珀酸生产菌的选育、其代谢机理与产酸条件、发酵过程工艺、产品提取等方面的研究现状。Succinic acid is an important four-carbon intermediate compound,serving as the starting material for producing bulk chemicals.It has a huge market for producing food and pharmaceutical products,surfactants,detergents, green solvents,biodegradable plastics,and feeds ingredients to stimulate animal and plant growth.Based on renewable resources and fixation of greenhouse gas CO_2,succinic acid produced by microbial fermentation has significant environmental advantages and attracted great interests recently.This paper reviews research on the screening and breeding of succinateproducing microorganisms,metabolic pathways,fermentation process,and separation technology in recent years.In order to establish a successful commercialization of bio-based succinate to compete with petrochemical-based succinate,further works should be focused on improving the strains performance,lowing cost of fermentative production,and using renewable resources.

关 键 词：生物基化学品 琥珀酸产生菌 代谢工程 发酵 提取工艺 生物质原料 

分 类 号：TQ922[轻工技术与工程—发酵工程]