小儿肾上腺神经母细胞瘤及瘤旁组织的蛋白质组学分析  

Proteomic Analysis of Children Adrenal Neuroblastoma and Adrenal Control Tissues

作　　者：王鸿丽[1] 刘洲禄[2] 李卫华[1] 赵永强[1] 刘炳玉[1] 李萍[1] 薛燕[1] 刘锋[1] 何昆[1] 张学敏[1] 杨松成[1] 

机构地区：[1]国家生物医学分析中心,北京100850 [2]中国人民解放军总医院小儿外科,北京100853

出　　处：《分析测试学报》2008年第S1期1-2,共2页Journal of Instrumental Analysis

摘　　要：In order to explore the molecular mechanisms of children adrenal neuroblastoma,and screen biomarkers for early diagnosis of this disease,the comparative proteomics were done in this report.The total proteins in children adrenal neuroblastoma and adrenal control tissues were extracted separately and then separated by 2-DE individually.The protein spots were identified eventually by UPLC-HD-MS.In this research,18 difference proteins including stathmin 1 were found.In order to explore the molecular mechanisms of children adrenal neuroblastoma,and screen biomarkers for early diagnosis of this disease,the comparative proteomics were done in this report.The total proteins in children adrenal neuroblastoma and adrenal control tissues were extracted separately and then separated by 2-DE individually.The protein spots were identified eventually by UPLC-HD-MS.In this research,18 difference proteins including stathmin 1 were found.

关 键 词：children ADRENAL NEUROBLASTOMA comparative PROTEOMICS UPLC-HD-MS 

分 类 号：R736.6[医药卫生—肿瘤]