Interaction Between HMG Proteins (1+2) and the Negative Regulatory Region 1(NCR1) in the 5'-flanking Sequence of the Human β-globin Gene  

作　　者：钱若兰 陈雅娣 胡玉龙 李民乾 王中怀 徐耀良 

机构地区：[1]Shanghai Institute of Cell Biology, Academia Sinica, Shanghai 200031, PRC [2]Shanghai Institute of Nuclear Research, Academia Sinica, Shanghai 201800, PRC

出　　处：《Science China Chemistry》1993年第8期933-939,共7页中国科学（化学英文版）

基　　金：This work was supported by grants from Academia Sinica.

摘　　要：The pattern of high mobility group proteins 1 and 2 (HMG1,2) interaction with the 5’-flanking sequence of the human β-globin gene has been analyzed by scanning tunnelling microscopy (STM). A 200 bp negative regulatory region in the 5’-flanking sequence of the human β-globin gene can be folded by HMG proteins 1 and 2 into a circular structure (diameter 70±6) with a linear tail which seems to be a left-handed double helix structure.The pattern of high mobility group proteins 1 and 2 (HMG1,2) interaction with the 5'-flanking sequence of the human β-globin gene has been analyzed by scanning tunnelling microscopy (STM). A 200 bp negative regulatory region in the 5'-flanking sequence of the human β-globin gene can be folded by HMG proteins 1 and 2 into a circular structure (diameter 70±6) with a linear tail which seems to be a left-handed double helix structure.

关 键 词：HMG protein STM Β-GLOBIN gene CHROMATIN FOLDING 

分 类 号：O6[理学—化学]