Study on the Relationship Between Depletion of O^6-Methylguanine-DNA Methyltransferase and Cancer Chemotherapy  

作　　者：陈建敏 章扬培 陈月能 吴英 范国才 

机构地区：[1]Beijing Institute of Radiation Medicine, Beijing 100850, PRC

出　　处：《Chinese Science Bulletin》1993年第6期501-505,共5页

基　　金：Project supported by the National Natural Science Foundation of China.

摘　　要：Drug resistance is still one of the major problems in cancer therapy. However, during the past several years, many efforts have been focused on reversing or depleting the molecular basis of drug resistance along with the elucidating of the mechanisms involved.Nitrosourea compounds such as 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and 1, 3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) are an important class of useful antitumor drugs. They exert their antitumor activity by alkylating the O^6 position of guanine and leading to a DNA interstrand cross-link. Introcellular O^6-methylguanine-DNA methyltransferase (O^6-MT) can repair the mentioned DNA lesions and thus plays an important role in determining the sensitivity of

关 键 词：O^6-methylguanine-DNA METHYLTRANSFERASE cancer CHEMOTHERAPY ACNU STREPTOZOTOCIN TUMOR cell lines. 

分 类 号：N[自然科学总论]