Toosendanin-induced Ca^(2+) Conductance Increase in Neuroblastoma×Giioma Hybrid Cells  

作　　者：施玉樑 Furuya Kishio 王文萍 Terakawa Susumu 徐科 Yamagishi Shunichi 

机构地区：[1]Shanghai Institute of Physiology, Academia Sinica [2]National Institute for Physiological Sciences

出　　处：《Chinese Science Bulletin》1993年第17期1489-1493,共5页

基　　金：This work was supported by National Institute for Physiological Science, Japan and the National Natural Science Foundation of China. Partial experiments were performed in Okazaki, Japan

摘　　要：Toosendanin (TSN), a triterpenoid derivative extracted from the bark of Melia toosendan Seib et Zucc and used in Chinese traditional medicine as an anthelmintic against ascaris, is a presynaptic neuromuscular blocker. Without affecting the nerve conduction, the muscle resting potential as well as acetylcholine (ACh) sensitivity of the muscle membrane at the end-plate region, TSN blocks the neuromuscular transmission selectively by inhibiting ACh release from the motor nerve terminals. It was interesting to notice

关 键 词：TOOSENDANIN NEUROBLASTOMA Ca²⁺ CONDUCTANCE membrane potential WHOLE-CELL recording. 

分 类 号：N[自然科学总论]