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Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress
《World Journal of Psychiatry》2025年第2期209-221,共13页Si-Hai Chen Bo Lan Ying-Ying Zhang Guo-Hui Li Yu-Long Qian Ming-Xing Hu Yin-Lin Tian Wei-Dong Zang Jing Cao Guang-Hai Wang Yi-Gang Wang 
Supported by the Natural Science Foundation of Xiaogan,China,No.XGKJ2023010036.
BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,b...
关键词：Zona incerta Gamma-aminobutyric acid-ergic DEPRESSION ANXIETY Animal behavior studies Whole-cell patchclamp 
Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases
《Synthetic and Systems Biotechnology》2024年第2期187-195,共9页Zetian Qiu Xiaohui Liu Jie Yu Yushuo Zhao Guang-Rong Zhao Shengying Li Kun Liu Lei Du Li Ma 
This work was supported by the National Key Research and Development Program of China(2021YFA0911500);the National Natural Science Foundation of China(32071266,32170088,and 32370032);the Shandong Provincial Natural Science Foundation(ZR2020ZD23);the State Key Laboratory of Microbial Technology Open Projects Fund(M2022-01).
Benzyl and phenylpropanoid acids are widely used in organic synthesis of fine chemicals,such as pharmaceuticals and condiments.However,biocatalysis of these acids has received less attention than chemical synthesis.On...
关键词：Benzyl acids Phenylpropanoid acids Alcohol dehydrogenases Aldehyde dehydrogenases Whole-cell catalysis 
Aberration correction for deformable-mirror-based remote focusing enables high-accuracy whole-cell super-resolution imaging
《Photonics Research》2024年第4期821-832,共12页WEI SHI YINGCHUAN HE JIANLIN WANG LULU ZHOU JIANWEI CHEN LIWEI ZHOU ZEYU XI ZHEN WANG KE FANG YIMING LI 
National Natural Science Foundation of China(62375116);Shenzhen Medical Research Fund(B2302038);Key Technology Research and Development Program of Shandong(2021CXGC010212);Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20220818100416036,KQTD20200820113012029);Startup Grant from Southern University of Science and Technology。
Single-molecule localization microscopy(SMLM)enables three-dimensional(3D)investigation of nanoscale structures in biological samples,offering unique insights into their organization.However,traditional 3D super-resol...
关键词：enable MIRROR RESOLUTION 
Efficient biosynthesis of creatine by whole-cell catalysis from guanidinoacetic acid in Corynebacterium glutamicum
《Synthetic and Systems Biotechnology》2024年第1期99-107,共9页Chunjian Li Pengdong Sun Guoqing Wei Yuqi Zhu Jingyuan Li Yanfeng Liu Jian Chen Yang Deng 
funded by National Natural Science Foundation of China(no.32272279);the Key R&D project of Qingdao Science and Technology Plan(22-3-3-hygg-29-hy).
Creatine is a naturally occurring derivative of an amino acid commonly utilized in functional foods and pharmaceuticals.Nevertheless,the current industrial synthesis of creatine relies on chemical processes,which may ...
关键词：CREATINE Corynebacterium glutamicum Whole-cell biocatalysis Guanidinoacetate N-Methyltransferase Food additive 
Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid
《Bioresources and Bioprocessing》2024年第1期753-762,共10页Yi-Ke Qi Jiang Pan Zhi-Jun Zhang Jian-He Xu 
the financial supports from the National Key Research and Development Program of China(Nos.2019YFA0905000&2022YFC2105900);National Natural Science Foundation of China(Nos.32071475&21536004).
Background Dodecanedioic acid(DDA),a typical medium-chain dicarboxylic fatty acid with widespread applications,has a great synthetic value and a huge industrial market demand.Currently,a sustainable,eco-friendly and e...
关键词：Linoleic acid Dodecanedioic acid Escherichia coli Whole-cell biosynthesis Multi-enzymatic cascade 
Artificial multi-enzyme cascades and whole-cell transformation for bioconversion of C1 compounds: Advances, challenge and perspectives
《Synthetic and Systems Biotechnology》2023年第4期578-583,共6页Yangyi Qiao Wenyue Ma Shangjie Zhang Feng Guo Kang Liu Yujia Jiang Yanxia Wang Fengxue Xin Wenming Zhang Min Jiang 
supported by National Key R&D Program of China(2022YFC2105900);the National Natural Science Foundation of China(22078151,22378199,21978130);Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20220052)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTD2215);Young Elite Scientist Sponsorship Program by CAST(YESS20200174).
Artificial multi-enzyme cascades bear great potential for bioconversion of C1 compounds to value-added chemicals.Over the past decade,massive efforts have been devoted to constructing multi-enzyme cascades to produce ...
关键词：SCALING PROOF utilizing 
Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst被引量：1
《Synthetic and Systems Biotechnology》2023年第4期741-748,共8页Chixiang Sun Baodong Hu Yanchun Li Zhimeng Wu Jingwen Zhou Jianghua Li Jian Chen Guocheng Du Xinrui Zhao 
supported by the National Key Research and Development Program of China(2019YFA0906400);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-08);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_2486);We thank Prof.Shengying Li(Shandong University,China)for providing plasmids pET28a-SelFdx1499 and pET28a-SelFdR0978.
Deoxycholic acid(DCA)has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat.The hydroxylated product(6β-OH DCA)was developed to improve the solubility and pharmaceutic proper...
关键词：OleP Deoxycholic acid HYDROXYLATION Redox partners Whole-cell catalysis 
Whole‑cell catalytic synthesis of trehalose by Corynebacterium glutamicum displaying trehalose synthase on its cell surface
《Systems Microbiology and Biomanufacturing》2023年第3期489-497,共9页Ming Fang Qiang Wang Zhi Wang Ruiqi Lu Rufan Xing Xian Zhang Zhiming Rao 
the National Natural Science Foundation of China(No.32171471);Key Research and Development Project of Shandong Province,China(2019JZZY020605);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.
Trehalose is a disaccharide with many applications in cosmetics,refrigeration,and food.Trehalose synthase is a significant enzyme in trehalose production.Escherichia coli is usually used to express this enzyme heterol...
关键词：Trehalose synthase Corynebacterium glutamicum Surface display Whole-cell catalyses 
NIR Light-Promoted Whole-Cell Catalysis Based on a Light-Harvesting Blackbody Bioreactor
《Journal of Analysis and Testing》2023年第3期237-244,共8页Jinhui Gu Qisi Li Mengting Cao Xiaojia Zhang Xinpei Ding Haiyan Chen Nan Wang Zhijun Zhang 
financially supported by the National Natural Science Foundation of China(NSFC)(22007083);Zhejiang Provincial Innovation Center of Advanced Textile Technology and the Fundamental Research Funds of Shaoxing Keqiao Research Institute of Zhejiang Sci-Tech University(KYY2022004C);the Fundamental Research Funds of Shengzhou Innovation Research Institute of Zhejiang SciTech University(SYY2023B000004)
Whole-cell catalysis,which utilizes enzymes expressed in whole organism(e.g.bacteria and fungi)as the catalyst,is a specific mode of biocatalysis.Compared with pure enzyme catalysis,the catalysis with whole-cell catal...
关键词：Whole-cell catalysis BIOCATALYSIS Photothermal eff ect Near-infrared light response Blackbody materials Porous sponge 
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function被引量：6
《Neural Regeneration Research》2022年第10期2253-2259,共7页Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang 
supported by the National Natural Science Foundation of China,Nos.81925031(to YT),81820108026(to YT),81972967(to WJL),81872549(to YL);the Youth Program of National Natural Science Foundation of China,No.81801229(to YTX);a grant from Guangdong Science and Technology Department of China,Nos.2020B1212060018(to WJL),2020B1212030004(to WJL);the Natural Science Foundation of Guangdong Province,No.2019A1515011754(to WJL);the Science and Technology Program of Guangzhou of China,No.202007030001(to YT);the Science and Technology Planning Project of Guangzhou of China,No.201704030033(to YL).
Radiation therapy is a standard treatment for head and neck tumors.However,patients often exhibit cognitive impairments following radiation therapy.Previous studies have revealed that hippocampal dysfunction,specifica...
关键词：GABA-mediated hyperfunction GluR intrinsic excitability long-term potentiation radiation-induced cognitive impairment spontaneous excitatory postsynaptic currents spontaneous inhibitory postsynaptic currents synaptic plasticity type I vesicular glutamate transporter vesicular GABA transporter whole-cell patch clamp recording 
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