A Study of the Pesticide Fenthion: Toxicity, Mutagenicity, and Influence on Tissue Enzymes  

作　　者：BAI CHENGLONG QIAO CIBING ZHANG WEIDONG CHEN YULI AND QU SHUXIN 

机构地区：[1]Department of’Toxicology.Shandong Academy of Medical Sciences,Jing 10 Road,Jinan 250001,China [2]The Affiliated Hospital of Shandong Medical University,Wen Hua Xi Road,Jinan 250012,China

出　　处：《Biomedical and Environmental Sciences》1990年第3期262-275,共14页生物医学与环境科学(英文版)

摘　　要： In this paper results of acute toxicitv (oral and dermal), cumulative toxicitv, subchronic toxicitv. and conjunctiva irritation tests are reported. The mutagenic effects of fenthion. using SCE (in vivo) and UDS(in vitro) as indicators, were also tested. Histochemical changes in enzyme activities (including AChE. ATPase. and AK.P) in tissues were observed. The results showed that the acute toxicitv of fenthion belongs to highly toxic category. The highly cumulative effect of fenthion was also observed. The subchronic toxicitv test. however. did not reveal any abnormal effects except the inhibition of ChE activity in plasma. The dose and ChE activity relationship equation was V=0.82.x+4.71. The SCE and UDS tests revealed no mutagenic potential. In histochemical experiments we found that AChE activity in tissues was markediv inhibited. AKP and ATPase activities at the cortex rcnis were increased in the treated rats.(c) 1990 Academic Press. Inc.In this paper results of acute toxicitv (oral and dermal), cumulative toxicitv, subchronic toxicitv. and conjunctiva irritation tests are reported. The mutagenic effects of fenthion. using SCE (in vivo) and UDS(in vitro) as indicators, were also tested. Histochemical changes in enzyme activities (including AChE. ATPase. and AK.P) in tissues were observed. The results showed that the acute toxicitv of fenthion belongs to highly toxic category. The highly cumulative effect of fenthion was also observed. The subchronic toxicitv test. however. did not reveal any abnormal effects except the inhibition of ChE activity in plasma. The dose and ChE activity relationship equation was V=0.82.x+4.71. The SCE and UDS tests revealed no mutagenic potential. In histochemical experiments we found that AChE activity in tissues was markediv inhibited. AKP and ATPase activities at the cortex rcnis were increased in the treated rats.(c) 1990 Academic Press. Inc.

关 键 词：In TOXICITY and Influence on Tissue Enzymes MUTAGENICITY 

分 类 号：R[医药卫生]