Changes of Lipid Peroxides and Superoxide Dismutase in Visceral Tissues during Endotoxic Shock in Rats  

作　　者：汪江淮 陈惠荪 刁有芳 田昆仑 王涛 

机构地区：[1]Research Institute of Field Surgery,Third Military Medical College,Chongqing 630038

出　　处：《Journal of Medical Colleges of PLA(China)》1990年第2期141-145,共5页中国人民解放军军医大学学报（英文版）

基　　金：This study was supported by the National Natural Science Fundation of China

摘　　要：As compared with the control,the malondialdehyde(MDA)levels in the cardi-ac,pulmonary,and intestinal tissues were elevated(P【0.05),and the superoxide dismu-tase activities in the cardiac,pulmonary,and intestinal tissues increased(P【0.05)at the30th min after endotoxic shock;the former in the cardiac,hepatic,renal,pulmonary,andintestinal tissues were elevated(P【0.05～0.001)and the latter in the cardiac,pulmona-ry,and intestinal tissues decreased in the 2nd h after shock;and the former were marke-dly elevated(P【0.01～0.001)and the latter severely decreased(P【【0.05～0.001)in allthe visceral tissues tested in the 4th h after shock.These data showed that lipid peroxid-ation mediated through oxygen-derived free radicals brought about tissue damage of theviscera listed above,which occurred earlier in the heart,the lungs and the intestines thanin the liver and the kidneys,and superoxide dismutase(SOD)activity was suppressed inthe late stage of endotoxic shock.As compared with the control,the malondialdehyde(MDA)levels in the cardi- ac,pulmonary,and intestinal tissues were elevated(P<0.05),and the superoxide dismu- tase activities in the cardiac,pulmonary,and intestinal tissues increased(P<0.05)at the 30th min after endotoxic shock;the former in the cardiac,hepatic,renal,pulmonary,and intestinal tissues were elevated(P<0.05～0.001)and the latter in the cardiac,pulmona- ry,and intestinal tissues decreased in the 2nd h after shock;and the former were marke- dly elevated(P<0.01～0.001)and the latter severely decreased(P<<0.05～0.001)in all the visceral tissues tested in the 4th h after shock.These data showed that lipid peroxid- ation mediated through oxygen-derived free radicals brought about tissue damage of the viscera listed above,which occurred earlier in the heart,the lungs and the intestines than in the liver and the kidneys,and superoxide dismutase(SOD)activity was suppressed in the late stage of endotoxic shock.

关 键 词：malondialdchyde superoxide disrnutase shock ENDOTOXIN free RADICAL RAT 

分 类 号：R[医药卫生]