66例9号染色体臂间倒位临床分析  

Clinical analysis in 66 cases of pericentric inversion of chromosome 9

作　　者：何瑶[1] 刘东云[1] 文建庆[1] 黄国宁[1] 

机构地区：[1]重庆市妇幼保健院遗传与生殖研究所,重庆400013

出　　处：《中国优生与遗传杂志》2011年第12期50-51,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨9号染色体臂间倒位的临床意义,分析inv(9)与生育障碍的关系。方法患者抽取外周血进行淋巴细胞培养,按常规方法制备染色体,G显带行核型分析。结果 6962例外周血中检出inv(9)66例,检出率0.95%,将6962例受检者分为正常生育组和生育障碍组,比较其inv(9)检出率,差异无显著性,并就各组资料行临床分析。结论 inv(9)对生育无确切不良影响,无确切病理学意义。Objective： To establish the clinical significance of pericentric inversion of chromosome 9 （inv（9）） and analyse therelationship between inv（9） and abnormal fertility. Methods： Chromosome preparations were made from peripheral blood lymphocytes. Karyotypes were analyzed by G - banding technique. Results： Among 6962 cases, 66 cases were found having inv （9） （0. 95 % ）. Dividing the 6962 cases into the normal fertility group and abnormal fertility group, the detectable ratio of inv（9） is no significant difference between them and making clinical analyze for each group. Conclusion： Inv（9） is no precise adverse effects for fertility, it generally speaking that inv（9） itself did not have pathological significance.

关 键 词：9号染色体 臂间倒位 临床意义 

分 类 号：R596[医药卫生—内科学]