不良孕产史夫妇的细胞遗传学分析  

Cytogenetic analysis of couples with abnormal pregnancy

作　　者：张清健[1] 郑立新[1] 田佩玲[1] 叶嘉玲[1] 杨卫[1] 王柏贤[1] 徐珊珊[1] 周冰燚[1] 赵文忠[1] 蔡慧娜[1] 方俊宇[1] 朱志勇[1] 

机构地区：[1]广东省计划生育科学技术研究所,广州510600

出　　处：《中国男科学杂志》2011年第11期28-30,共3页Chinese Journal of Andrology

摘　　要：目的探讨不良孕产与染色体异常和多态的关系。方法对573对不良孕产史夫妇进行常规染色体G显带分析，并对不良孕产史夫妇和普通人群染色体异常和多态染色体的发生率进行统计学分析。结果染色体平衡易位、倒位以及染色体多态中Y染色本的长臂延长（Yqh＋）在不良孕产史夫妇组与普通人群的发生率有统计学差异；而罗氏易位和9号染色体臂间倒位[inv（9）]在两组的发生率无统计学差异。结论染色体结构异常是导致不良孕产的重要原因之一，染色体多态中Yqh＋也可导致不良孕产，而inv（9）可能不会导致不良孕产。Objective To investigate the relationships between abnormal pregnancy and chromosome aberration and chromosomal polymorphism. Methods Chromosome specimens were made using routine culture of peripheral blood lymphocytes. Karyotyping was conducted mainly by G banding. Statistical analysis was performed on the occurrence rates of chromosome aberration and chromosomal polymorphism between abnor- mal pregnancy couples and the general population. Results There were statistical differences in the occurrence rates of balanced translocation, inversion and Yqh＋ between abnormal pregnancy couples and the general population. But no statistical differences in the occurrence rates of robertsonian translocation and inv（9） were found between two groups. Conclusion Abnormal chromosomes structure might beone of the most important reasons for abnormal pregnancy. And Yqh＋,but no inv（9）, might cause abnormal pregnancy in the carriers.

关 键 词：妖娠/遗传学 染色体畸变 

分 类 号：R394.2[医药卫生—医学遗传学] R714.2[医药卫生—基础医学]