Functions of chromatin remodeling factors in heterochromatin formation and maintenance  

作　　者：BI Xin 

机构地区：[1]Department of Biology, University of Rochester, Rochester, NY 14627, USA

出　　处：《Science China(Life Sciences)》2012年第1期89-96,共8页中国科学（生命科学英文版）

基　　金：supported by U.S. National Institutes of Health (Grant No. GM62484)

摘　　要：Heterochromatin is characteristically more compact than chromatin is mediated by special histone modifications, euchromatin in the eukaryotic genome. The establishment of hetero- recruitment and propagation of heterochromatin specific proteins, as well as formation of special primary and high order structures of chromatin. Chromatin remodeling factors are ATPases that can alter the conformation and/or positioning of nucleosomes along DNA in an ATP-dependent manner. There is increasing evidence implicating chromatin remodeling activities in heterochromatin in various organisms ranging from yeasts to humans. Chromatin remodeling factors play roles in the establishment, maintenance and epigenetic inheritance of heterochromatin, but the underlying molecular mechanisms have just begun to be investigated.Heterochromatin is characteristically more compact than euchromatin in the eukaryotic genome. The establishment of heterochromatin is mediated by special histone modifications, recruitment and propagation of heterochromatin specific proteins, as well as formation of special primary and high order structures of chromatin. Chromatin remodeling factors are ATPases that can alter the conformation and/or positioning of nucleosomes along DNA in an ATP-dependent manner. There is increasing evidence implicating chromatin remodeling activities in heterochromatin in various organisms ranging from yeasts to humans. Chromatin remodeling factors play roles in the establishment, maintenance and epigenetic inheritance of heterochromatin, but the underlying molecular mechanisms have just begun to be investigated.

关 键 词：chromatin remodeling gene silencing HETEROCHROMATIN INHERITANCE NUCLEOSOME REPLICATION 

分 类 号：Q343.2[生物学—遗传学] Q243