高龄孕妇的细胞遗传学效应实验室分析  

Laboratory analysis of cytogenetic effect in older pregnant women

作　　者：毛倩倩[1] 邹波[1] 鲁莉萍[1] 

机构地区：[1]浙江省宁波市妇女儿童医院检验科,浙江宁波315012

出　　处：《中国卫生检验杂志》2012年第3期493-494,497,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:对高龄孕妇孕中期行胎儿细胞遗传学研究,并探讨其临床效应。方法:采用羊水细胞培养,应用G、C和Nor带分析确定染色体核型以及不同高龄组的异常染色体检出率。结果:2624例高龄(年龄≥35岁)孕妇羊水细胞培养中,发现胎儿染色体异常核型157例,异常发生率5.98%(157/2624)。共检出有临床意义组的染色体异常48例,发生率为1.87%(48/2624);没有临床意义组的染色体异常109例,发生率为4.11%(108/2624)。其中三体征39例(35岁～40岁年龄组28例,异常率1.16%;40岁以上年龄组11例异常率5.29%),经统计学分析两组之间差异有统计学意义(χ2=40.86,P<0.01)。结论:高龄孕妇所孕胎儿发生染色体异常率高;40岁以上孕妇尤为突显;高龄孕妇应加强产前诊断意识。Objective： To study fetal cytogenetics in older prenatal women and its clinical effects.Methods： Amniotic fluid cell culture was chosen in this study.G,C and Nor bands were used to determine the karyotype and the detection rate of chromosomal abnormalities.Results： 157 cases were found fetal chromosome abnormal karyotype from 2624 elderly（age≥35） pregnant women,with the incidence of 5.98%（157/2624）,in which 48 cases were in group with clinical significance,1.87%（48/2624）,while 109 were in group without clinical significance,4.11%（109/2624）.39 trisomy cases were found with 28 cases in group aged 35 to 40（1.16%） and 11 cases in group over 40 years old（5.29%）,the statistical analysis of the difference between the two groups was significant（χ2=40.86,P0.01）.Conclusion： The elderly pregnant women had the highest chromosome abnormal rate,especially pregnant women over 40 years old.Elderly pregnant women should be strengthened the awareness of prenatal diagnosis.

关 键 词：高龄孕妇 胎儿 染色体异常 产前诊断 

分 类 号：R714.55[医药卫生—妇产科学]