新型2-芳氨基均三嗪衍生物的合成  

Synthesis of Novel 2-(Substituted anilino)triazine Derivatives

作　　者：董金付[1] 余聂芳[1] 

机构地区：[1]中南大学药学院分子设计与药物发现研究所,湖南长沙410013

出　　处：《广州化工》2012年第8期68-69,77,共3页GuangZhou Chemical Industry

基　　金：国家自然科学基金(No:30873137)

摘　　要：以三聚氯氰为起始原料,经由烃化反应、Suzuki偶联反应、格氏反应等组成的两条不同的合成路线合成了2个结构新颖的2-芳氨基均三嗪衍生物,其结构经1H NMR,MS等确证。同时对格氏反应条件进行了实验探索,得到了反应收率较高的实验条件。Two novel 2 - aniline - s - triazine derivatives were prepared from cyanuric chloride by two diiterent syn- thetic routes of alkylation reaction, suzuki coupling reaction and Grignard reaction. The structures of the compounds were confirmed by 1H NMR and MS. A large number of experiments were carried out to find out the Grignard reaction condi- tions with high yeild.

关 键 词：均三嗪衍生物 SUZUKI偶联反应 格氏反应 

分 类 号：R914.5[医药卫生—药物化学]