富铬鸡腿蘑菌丝发酵液急性毒性和降血糖作用的初步研究  

FERMENTED MASH OF COPRINUS COMATUS RICH IN CHROMIUM(FCRC) CAN BRING DOWN HIGH LEVEL OF BLOOD GLUCOSE

作　　者：王玉萍[1] 李翔太[1] 尹进[2] 高春蕾 

机构地区：[1]山东大学微生物技术国家重点实验室,山东济南250100 [2]山东省医学科学院基础医学研究所,山东济南250016

出　　处：《山东大学学报（自然科学版）》2000年第1期117-120,共4页Journal of Shandong University(Natural Science Edition)

基　　金：山东省科委"九五"攻关项目!( 971 1 64 81 9)

摘　　要：采用深层发酵的方法获得富铬鸡腿蘑发酵液 (FCRC) .急性毒性试验证明 ,每公斤体重用量达 2 6g不引起小鼠中毒 ,表明该制剂无急性毒性 .在四氧嘧啶诱发的小鼠糖尿病模型上进行降血糖试验的结果表明 ,FCRC有对抗化学药物导致高血糖的可能性 ,并对糖尿病模型小鼠有降血糖作用 .To make fermented mash of coprinus comatus rich in chromium (FCRC)by liquid ferment.The acute toxicity of FCRC was evaluated on kunming'mice.The result shows that FCRC are innocuous.Making mice with diabetes was by in jecting alloxan.The diabetes probability of mice they had taken the FCRC is less than that of mice they hadn't.The high level of blood glucose of diabetes model mice has dropped when they had taken the FCRC.

关 键 词：鸡腿蘑 液体发酵 铬 急性毒性 降血糖作用 FCRC 

分 类 号：R931.71[医药卫生—生药学] R965.3[医药卫生—药学]