Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor  

作　　者：Mei-Yi Wu Junjiang Fu Jianming Xu Bert W O＇MaUey Ray-Chang Wu 

机构地区：[1]Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC 20037, USA [2]The Research Center for Preclinical Medicine, Luzhou Medical College, Luzhou City, Sichuan 646000, China [3]Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA

出　　处：《Cell Research》2012年第6期1003-1021,共19页细胞研究（英文版）

摘　　要：SRC-3/AIB1 （steroid receptor coactivator 3/amplified in breast cancer 1） is an authentic oncogene that contributesto the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identified macrophage migration inhibitory factor （MIF） as a novel target gene of SRC-3 and demonstrated its importance in cell survival Specifically,

关 键 词：SRC-3 MIF AUTOPHAGY TUMORIGENESIS CHEMOSENSITIVITY 

分 类 号：Q279[生物学—细胞生物学] Q71