基于进化树理论的甲型流感病毒血凝素同源性及进化分析  

Influenza Virus A Hemagglutinins Homology and Evolution Analysis Based on the Evolutionary Tree Theory

作　　者：王伟[1] 仇建烨[1] 吴艳[1] 朱平[1] 

机构地区：[1]江南大学理学院,江苏无锡214122

出　　处：《工程数学学报》2012年第4期507-515,共9页Chinese Journal of Engineering Mathematics

基　　金：财政部环保公益性行业科研专项资助(200909070);江南大学创新团队发展计划(PIRTJiangnan2008CX002)~~

摘　　要：甲型流感病毒(influenza virus A)可以感染禽类,哺乳类等动物,威胁着人类健康.本文分别选取了甲型流感病毒的血凝素(HA)的16种亚型一定数量的序列,利用MEGA(Molecular Evolutionary Genetics Analysis)4.0软件对其做同源性分析,构建HA的系统进化发生树,找出它们进化的规律,并结合2010年我国从人体分离的甲型流感病毒株的情况,利用Genbank的BLAST功能做同源性搜索,结合HA的进化树分析了我国甲型流感病毒株的现状,从而预测了潜在的甲型流感病毒血凝素对人体的威胁.Influenza virus A can infect birds, mammals and other organisms, and greatly threat human health. This paper selects a certain number of sequences from 16 kinds of subtypes of HAs, uses MEGA4.0 software to analyze the homology, meanwhile, constructs the evolutionary tree, and finds out the evolutionary law. Combined with the HA strains which were separated from human case in 2010, we analyze the current situation in China by using the BLAST function of Genbank, and predict the potential threat to human of influenza virus.

关 键 词：甲型流感病毒 血凝素 同源性 系统进化树 同源搜索 

分 类 号：Q811.4[生物学—生物工程] O29[理学—应用数学]