滁菊总黄酮对大鼠急性心肌缺血保护作用的实验研究  

Study on the effect of chuju total flavonoids on actue myocardial ischemia in rats

作　　者：俞浩[1] 周国梁[1] 刘汉珍[1] 周金星[1] 杨剑婷[1] 

机构地区：[1]安徽科技学院食品药品学院,安徽凤阳233100

出　　处：《食品工业科技》2012年第13期352-354,358,共4页Science and Technology of Food Industry

基　　金：安徽省自然科学基金项目(10040606Q13);科技部科技人员服务企业行动项目(2009GJC30034);安徽科技学院稳定人才项目(ZRC2011297)

摘　　要：目的:观察滁菊总黄酮对大鼠急性心肌缺血的保护作用。方法:采用结扎冠状动脉左前降支复制急性心肌缺血大鼠模型,观察滁菊总黄酮对急性心肌缺血大鼠Ⅱ导联心电图J点、心肌梗死范围、血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)活性及丙二醛(MDA)、血栓素(TXB2)、6-酮-前列环素(6-Keto-PGF1α)含量的影响。结果:滁菊总黄酮能够明显抑制AMI大鼠心电图J点抬高,减小心肌梗死范围,升高血清中SOD活性和6-Keto-PGF1α含量,降低血清CK、LDH活性及MDA、TXB2含量,与模型组比较具有显著性差异(p<0.05或p<0.01)。结论:滁菊总黄酮对大鼠急性心肌缺血有保护作用。Objective.To observe the effect of chuju total flavonoid on acute myocardial ischemia in rats. Methods： The rats model of acute myocardial infarction were induced by ligating anterior branch of the left coronary artery. The II lead electrocardiograms and the infarction area of myocardium were analyzed,the activities of LDH,CK and SOD in serum were assayed,the concentration of MDA,TXB2 and 6-Keto-PGF1α in serum were also determined. Results.Chuju total flavonoid could obviously refrain the elevated J of ECG,decrease the infarction area of myocardium,increase the activity of SOD and the concentration 6-keto-PGF1α,reduce the activities of CK,LDH and the concentrstion of MDA and TXB2 in serum comparing with model rats（p〈0.05 or p〈0.01 ）.Conclusion.Chuju total flavonoid has the protective effect on acute myocardial ischemia in rats.

关 键 词：滁菊总黄酮 大鼠 急性心肌缺血 脂质过氧化 血小板功能 

分 类 号：TS201.4[轻工技术与工程—食品科学]